Milwaukee Panthers vs Indiana Hoosiers Prediction, Odds and Picks for Today, 11/12/25

The Indiana Hoosiers host the Milwaukee Panthers on Tuesday night in what could be an interesting matchup. The Hoosiers are off to a strong start under new head coach Darian DeVries, most notably notching a 23-point win at Marquette. Tucker DeVries (yes, the coach’s son) dropped 27 of Indiana’s 100 points in that game. He is a pure scorer, especially from deep, and he is the leader of a team that is almost entirely rebuilt under a new coaching staff. The Hoosiers will host Milwaukee Tuesday, a team that is off to a 2-1 start with wins over Hampton and Little Rock and a loss at Wofford. Indiana should win this game, but I think Milwaukee is good enough to keep this game closer than the 24.5-pt spread. I’ll take Milwaukee to cover.

The Hoosiers have some talent, and I think they are good enough to make it to the tournament, but they have looked far better than that so far. Personally, I am surprised at their pace of play and offensive production, particularly since DeVries led some slow and brutally-defensive teams at Drake. Against Marquette, Indiana shot 50% from the floor, including 50% from 3 and a ridiculous 27 assists. I do not think that is sustainable, and this will probably be an outlier game in a couple weeks via hindsight. On the other side, Milwaukee is probably the best team in the Horizon League, and they are capable of scoring, even if they give up a lot of points too. I think they can be competitive, especially if Indiana comes back down to earth a little bit. Give me the Panthers to cover the large spread on the road.

Milwaukee vs Indiana Prediction: Milwaukee +24.5 (-105) available at the time of publishing. Playable at that number.

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