Northern Illinois Huskies vs UMass Minutemen Prediction, Odds and Picks for Today, 11/12/25

The Northern Illinois Huskies and Massachusetts Minutemen meet Wednesday night at Warren McGuirk Alumni Stadium in Amherst, Massachusetts, and neither of these teams are eligible for a bowl, so they’re just playing out the string. NIU was humbled 42-3 last time out at Toledo, coming nowhere near a cover as a 16.5-point underdog, and the Huskies are just 1-6 against the spread (ATS) in the past seven games. A reason they’ve struggled so much lately, allowing 42 or more points in the past two games, and 38 or more points on the road in three of the past four outings. The Over has cashed in two in a row on the road, while going 3-2 in the past five outings.

UMass has had another awful season, as the defense just hasn’t made any inroads. It has allowed 41.0 PPG in the past two games, and 27 or more points in four in a row, and eight of nine games this season. At home, the Over is 3-1 in four games. Defensively, the Minutemen have allowed 441.8 total yards, 253.2 passing yards and 188.6 rushing yards with 36.8 points per game this season. Each of those marks are among the worst in the nation. Even NIU, which has struggled offensively, should be able to toss up at least 30 points, and UMass should be able to get theirs, too, against a Huskies defense not playing well lately.

Northern Illinois vs UMass prediction: Over 43.5 (-110) available at time of publishing. Playable to 44.5.

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