DET Lions @ ARZ Cardinals predictions . View computer picks, betting trends, injury report and team statistics below.

Against The Spread Pick

All eyes will be on rookie quarterback Kyler Murray as he starts his first NFL game against the Detroit Lions in front of his home crowd Sunday. The lines for this game have moved a lot in favor of Detroit. It started as a Pick em game and the Lions are now -2.5 favorites. Nobody wants to put money on the rookie, but maybe there is a good reason why. Looking back at the past three seasons for the Lions, they have a record of 1-5 in the first two road games of the season. Not to mention, Matthew Stafford comes into this season coming off his worst year ever with the Lions. A lot is on the line for the Lions. They have to stop the duo threat of Murray and Johnson in the backfield. I expect head coach Kliff Kingsbury to draw up the perfect plan for Murray for this Week 1 matchup, mainly because nobody has really seen what he can do. I do expect the Cardinals to struggle more down the road (once teams figure out how to stop Murray) but for right now, they squeeze past the Lions with a huge win. The Home team is 12-2 ATS in their last 14 meetings.

Over Under Pick

To go along with my earlier statements, Kingsbury is going to have a couple of drives already in place for Murray which will succeed against a team that has no idea what to expect. Expect a high scoring first half as both teams figure each other out late in the game. Regardless of when they figure each other out, points will be scored and often. The Over is 10-4 in the last 14 meetings and Over 11-1 in Lions last 12 games in Week as well as 4-1 in Lions last 5 games in September. Ride with the public here and take the OVER!

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