NFL week six picks against the spread and straight up for every game this week. Get our free NFL week six expert picks below. Get free NFL picks every week of the season.

Thu, Oct 10th - 8:20pm ET:
New York Giants @ New England Patriots

New York Giants
New England Patriots
NE Patriots -16.5 Point Spread
-105
Under 43.0 Game Totals
-111

Against the Spread Pick

Thursday Night Football here as the New England Patriots host the New York Giants in a game that’s expected to be lopsided. I don’t usually like laying it with favorites this large, but you have to do it here. New England has been dominant this season, and the Giants are extremely banged up. Saquon Barkley is still going to be sidelined with his ankle injury and the running back who took over for him, Wayne Gallman, is going to miss this game with a concussion. New York will also be without their best receiver in Sterling Shepard, and Evan Engram is looking questionable with a knee injury. Daniel Jones has flashed some promise, but he’s also made plenty of mistakes, and he’ll now be tasked with going on the road in primetime against one of the league’s best defenses. The Giants’ defense is a bottom-five unit, and Tom Brady should have no problem picking apart their sieve-like secondary. The Patriots are going to win this one by 20+.

Over Under Pick

I also think the under makes some sense here, because the Patriots aren’t going to score enough to send this one over by themselves. When Jones and the Giants had to play one of the league’s other top defenses in Minnesota this past week, they only put up ten points. That game was at home, and now they’re going on the road in primetime on a short week, with a depleted offense. They’ll be missing almost their entire starting offense, and Jones is getting thrown to the Wolves here against a Patriots defense that has only given up two offensive touchdowns the entire year. New England’s offense quietly hasn’t been that great the past few weeks, so I think New York will be able to limit them just enough to keep this one under.

Sun, Oct 13th - 9:30am ET:
Carolina Panthers @ Tampa Bay Buccaneers

Carolina Panthers
Tampa Bay Buccaneers
CAR Panthers -2.0 Point Spread
-111
Over 48.0 Game Totals
-111

Against The Spread Pick

The Carolina Panthers are ready for some revenge as they head into this game traveling across the pond to take on the Tampa Bay Buccaneers in London. The Panthers will be looking to avenge their Week 2 loss to the Bucs and further continue their division/playoff hopes without Cam Newton. Even though the Buccaneers held CMC to only 53 total yards in their previous matchup, the star running back has a second wind with new quarterback Kyle Allen at the helm. In the last three games, CMC has totaled over 600 total yards, or 200 all-purpose yards, per game. Even though this is on a neutral site, expect the Panthers to steamroll all over the Buccaneers. Tampa Bay is 0-2 straight up in its two all-time games played in London as Carolina is 4-2 against the spread in its last six games. Give me the Panthers in this London game.

Over Under Pick

The Carolina Panthers have a new life with Allen leading the team. They are undefeated with him and the offense is dropping 29.33 points per game in that span. This is going to be another explosive game for the Panthers and they are going to run wild over the Buccaneers. Tampa Bay is allowing nearly 400 yards per game (393.4 yards) and this has revenge written all over it. The Over is 5-1 in Panthers last 6 games in Week 6 as well as 5-1 in Panthers last 6 games following a straight-up win. Carolina is ranked 7th in the league for 2nd half points as they are dropping 14.4 points. Even if the Buccaneers put on a show in the 1st half, do not count out the Panthers. Give me the Over here.

Sun, Oct 13th - 1:00pm ET:
Philadelphia Eagles @ Minnesota Vikings

Philadelphia Eagles
Minnesota Vikings
MIN Vikings -3.0 Point Spread
-105
Under 44.0 Game Totals
-111

Against the Spread Pick

The Minnesota Vikings bounced back in the face of relentless criticism to beat the Giants in Week 5, but can they keep it going here in Week 6 against the visiting Philadelphia Eagles? The Eagles are coming off a win over the Jets, but they didn’t look too impressive despite facing one of the worst teams in the league. Carson Wentz threw for only 189 yards, and the running game averaged only 2.9 yards per attempt. Kirk Cousins had a great game for the Vikings, and I think he’ll be able to build on that momentum against an Eagles secondary that might be the most injured unit in the league. Philly’s cornerback situation is a mess right now, and they don’t stand a chance against Adam Thielen and Stefon Diggs. Wentz hasn’t been great this season, and the Eagles aren’t playing like the Super Bowl contenders many expected them to be. The Vikings still have an elite defense, and you should lay it with them here.

Over Under Pick

I also like the under in this spot. Wentz and the Eagles’ offense just struggled mightily in Week 5, and that was against the Jets. If they could only produce 265 yards of total offense against Gang Green, they don’t stand a chance on the road in Minnesota. The Vikings stubbornly like to run the ball as much as possible, but I don’t think Dalvin Cook will have much success against this elite Philly defensive front anchored by defensive tackle Fletcher Cox. Cousins is as erratic as they come, and he isn’t going to send this one over by himself. This should be a fairly low-scoring game.

Sun, Oct 13th - 1:00pm ET:
New Orleans Saints @ Jacksonville Jaguars

New Orleans Saints
Jacksonville Jaguars
JAX Jaguars -1.5 Point Spread
-111
Under 44.5 Game Totals
-111

Against the Spread Pick

Two quarterbacks who were suddenly thrust into starting roles will do battle here as Gardner Minshew and the Jacksonville Jaguars host Teddy Bridgewater and the New Orleans Saints. Bridgewater has won three straight games since taking over for Drew Brees, but I think that streak comes to an end here. Bridgewater hasn’t actually done anything special, and he barely ever throws the ball more than five yards downfield. The Jags are coming off a close road loss to the Panthers, but Minshew looked very good. He’s looked better than Bridgewater here, and Jacksonville’s running game has been having a recent resurgence. Bridgewater will get exposed now that he’s going on the road against a tough defense, and I absolutely love this spot for the Jaguars. This Saints defense is vulnerable to opposing passing attacks, and I think Minshew will be able to exploit it. The Saints are used to playing in a dome, so playing in this Florida heat will be a big disadvantage for them.

Over Under Pick

The under also makes some sense here. Both teams will be looking to take the load off their quarterbacks and establish the run, which will keep the clock churning. Bridgewater hasn’t really been tested yet, and I think he’s in for a tough day. The Jags still have a ferocious pass-rush with Calais Campbell and Josh Allen, and I think they’ll get after him. Minshew is still pretty inexperienced, and the Saints have a tough defensive front. He’ll be able to do enough to get the win, but he’s not going to light up the scoreboard here. This will be a sleepy game.

Sun, Oct 13th - 1:00pm ET:
Seattle Seahawks @ Cleveland Browns

Seattle Seahawks
Cleveland Browns
CLE Browns +2.0 Point Spread
-111
Over 47.5 Game Totals
-111

Against the Spread Pick

Two teams trending in opposite directions will clash here as the Cleveland Browns host the Seattle Seahawks. Seattle is riding high off a Thursday night victory, and enters this one at 4-1. The Browns on the other hand have hit rock-bottom, and are reeling after an embarrassing Monday night loss to the 49ers. Cleveland is being piled on by the media, and the criticism for Baker Mayfield and Freddie Kitchens has been relentless. The Browns will have a massive chip on their shoulder all week, and they should come out with their best effort here at home. The Seahawks have been getting really lucky, and they only won their most recent game because Greg Zuerlein missed a kick in the final seconds that he makes nine times out of ten. We’ve got a west coast team heading east for an early kick, and I think the Seahawks will be a bit complacent with their recent success. Mayfield usually responds well to adversity, and the Browns shouldn’t be home underdogs here.

Over Under Pick

I also like the over in this spot. Cleveland is going to come out on fire offensively, and I think they’ll have a lot of success against this overrated Seahawks defense. Seattle just got gashed by the Rams in their most recent game, and even Andy Dalton managed to throw for over 400 yards against them earlier this season. Cleveland has plenty of weapons, and I’d expect them to be aggressive early on as they look to put their recent struggles behind them. The Browns’ secondary is still pretty banged up, so Seattle should have some success through the air as well.

Sun, Oct 13th - 1:00pm ET:
Houston Texans @ Kansas City Chiefs

Houston Texans
Kansas City Chiefs
KC Chiefs -4.5 Point Spread
-111
Under 55.0 Game Totals
-111

Against the Spread Pick

Exciting matchup here as we get to see Patrick Mahomes square off with Deshaun Watson for the first time. The Chiefs are coming off their first loss of the season, a disappointing defeat at the hands of the Colts on Sunday Night Football. They’re also pretty banged up at the moment, and you’ll need to monitor their injury report. Even with all the injuries, I still like the Chiefs to cover this spread. I’m not a fan of this Texans coaching staff, and their defense is still a mess, as evidenced by the fact they just gave up 32 points to the Falcons. Mahomes is capable of dominating anyone, even if his ankle is tweaked. Quietly this Kansas City secondary is a lot better than it was last year, and I think they’ll be able to slow down Watson enough. Houston’s cornerbacks must have Andy Reid licking his chops, and he should be able to scheme up plenty of easy completions for Mahomes. Lay the points here.

Over Under Pick

I also like the under in this spot. Mahomes’ ankle seemed to really be bothering him during their loss to the Colts, and he won’t be 100 percent here. Kansas City also has some injuries on their offensive line which should depress their scoring. I’m pretty high on this Chiefs pass-defense, and they’re 11th in the league in yards per attempt allowed. Tyrann Mathieu has really helped the secondary, and I think Watson will struggle like he often does on the road. The Chiefs also have an underrated pass-rush, with new acquisition Frank Clark leading the way. This won’t be the shootout many are expecting.

Sun, Oct 13th - 1:00pm ET:
Washington Redskins @ Miami Dolphins

Washington Redskins
Miami Dolphins
MIA Dolphins +3.5 Point Spread
-111
Under 41.0 Game Totals
-111

Against The Spread Pick

The biggest game of the century will be played in Week 6 as the “Tank Bowl” will take place in Miami between the Washington Redskins and Dolphins. Both of these teams are horrible, however, there is a clear advantage in this game. Miami comes into this game off a bye and they have had over two weeks to prepare for this showdown. Another positive note is that quarterback Josh Rosen has slowly started to play well. In the loss against the Chargers, Rosen went 12-of-16 for 169 yards with a touchdown and no turnovers in the first half. The second half was more of a disaster as he only had 11 passing yards, but this small sign of promise will help big against the Redskins. The Redskins are 0-5 SU in their last 5 road games vs the Dolphins and giving three extra points to a home team that is well-rested is perfect in this matchup. Give me the Dolphins as they cover this game.

Over Under Pick

Long story short, both of these offenses are horrible. The Dolphins and Redskins are ranked 32nd and 31st in the league for 2nd half points. The Fins have scored zero points in the 2nd half while the Redskins have averaged less than a touchdown with 6.6. Both teams have under 300 total yards per game and there will be no movement in this game. The offenses will struggle especially with both defenses hoping to showcase why they deserve that first win. The total has gone UNDER in the Dolphins’ last 3 games as well as in the Redskins’ last 3 games vs the Dolphins. Give me the Under here.

Sun, Oct 13th - 1:00pm ET:
Cincinnati Bengals @ Baltimore Ravens

Cincinnati Bengals
Baltimore Ravens
CIN Bengals +11.5 Point Spread
-111
Over 48.0 Game Totals
-111

Against The Spread Pick

The Cincinnati Bengals are  on the road once again in Week 6 as they head to Baltimore to take on the Ravens. Even though the Bengals come into this game without a win, they sure can play for head coach Zac Taylor. They simply fall apart in the 4th quarter and cannot finish games. However, the 12 points they are getting in this game should be plenty to cover as they have kept close in all games this season. The Bengals lost on the road to Seattle and Buffalo and to the Cardinals last week. Diving deeper into those games, the Bengals lost by a combined eight points with the Seattle and Cardinals losses happening in the final minutes. Expect the Bengals to cover here with ease and there might even be an upset against this Ravens team as Andy Dalton should have enough time to throw on them. The Bengals are 4-1 ATS in their last 5 meetings in Baltimore as well as the Underdog being 8-2 ATS in their last 10 meetings. Give me the Bengals here big.

Over Under Pick

Even though the Bengals will keep this game close, do not expect the Ravens to have trouble scoring. The Ravens should have no problems showcasing their No. 1-ranked rushing game to run all over the Bengals’ last-place rushing defense. All of these divisional home games have been close for the Ravens as they have yet to cover one in the past six goes. It will be another high scoring game here and the Over is 4-0 in Ravens last 4 vs. AFC as well as 4-1 in Ravens last 5 games overall. Give me the Over here as this game hits near 55 total points.

Sun, Oct 13th - 4:05pm ET:
San Francisco 49ers @ Los Angeles Rams

San Francisco 49ers
Los Angeles Rams
LA Rams -3.5 Point Spread
-111
Under 50.5 Game Totals
-111

Against the Spread Pick

NFC West clash here as the San Francisco 49ers travel to Los Angeles to take on the Rams. This match will feature two of the best offensive minds in the game here in Kyle Shanahan and Sean McVay, which is always fun. Unfortunately for the 49ers, Shanahan is at a big disadvantage. He’s preparing with less time as San Fran played on Monday night, while McVay has extra prep time thanks to the Rams playing on Thursday. The Rams have lost back-to-back games, and they aren’t going to lose a third. They should’ve won last Thursday night, and would’ve if Greg Zuerlein didn’t uncharacteristically miss a field goal in the final seconds. The 49ers are being hyped up by everyone, but I’m still not sold. They’ve played a ridiculously easy schedule up to this point, and I think Jimmy Garoppolo gets exposed here. McVay with extra time to scheme would have any defensive coordinator quivering, and the game plan should be excellent. The Rams have a big chip on their shoulder here, and this line has been artificially deflated.

Over Under Pick

I’m also playing the under here. This is going to be Garoppolo’s toughest test, and this is the perfect time to sell-high on this 49ers offense. Aaron Donald has a history of dominating San Francisco, and he should wreck their plans yet again. Garoppolo and Shanahan have gotten most of the attention, but the 49ers’ defense is the real story of this team. Dee Ford and Nick Bosa have formed a suddenly elite pass-rushing duo, and they should be able to get after Jared Goff here. Goff hasn’t been good this year, and both defenses should have some success.

Sun, Oct 13th - 4:05pm ET:
Atlanta Falcons @ Arizona Cardinals

Atlanta Falcons
Arizona Cardinals
ARZ Cardinals +2.5 Point Spread
-105
Over 52.0 Game Totals
-111

Against The Spread Pick

The Atlanta Falcons are hoping to turn around their season and fast as they head into this road game to take on the Arizona Cardinals. The biggest news of this matchup is Cardinals running back David Johnson who might not play in this one. He suffered a back injury in the team’s 26-23 Week 5 win over the Cincinnati Bengals. He was able to finish the game, but his lower back was tight all game according to coach Kliff Kingsbury. Speaking of the rookie coach, he is coming off his best offensive performance yet totaling 514 total yards, 266 of them on the ground in their first win. This Arizona offense is finally starting to heat up and they are getting some free points in this game against a Falcons team which has been among the worst this season. Right now Dan Quinn is on the hot seat and this could be the final nail in the coffin if he loses this game. There is no reason why the Falcons should be the favorite as they are 2-10 ATS in their last 12 games on the road and 1-9 ATS in their last 10 games in October. Give me the Cardinals as they are fine with or without David Johnson.

Over Under Pick

On average, the Cardinals head to the red zone at least four times per game, but the biggest issue for them has been scoring touchdowns. So far this season, they have only averaged to score a touchdown on 30% of their trips. However, there should be all smiles for the Cardinals offense as the Falcons defense is allowing touchdowns 77% of the time in the red zone. Arizona should have no problems moving the ball downfield and scoring with ease. On the flip side, Atlanta should also move the ball with ease as Arizona is allowing over 400 total yards per game. The Over is 5-1 in the last 6 meetings in Arizona as well as 11-3 in the last 14 meetings. Give me the Over to win big here.

Sun, Oct 13th - 4:25pm ET:
Tennessee Titans @ Denver Broncos

Tennessee Titans
Denver Broncos
DEN Broncos -2.5 Point Spread
-111
Under 39.0 Game Totals
-111

Against The Spread Pick

The Denver Broncos come into this Week 6 matchup smiling after their first win of the season. And it was a big one against the Los Angeles Chargers on the road. Now the Broncos return home to take on the struggling Titans. For the Titans, they have one win on the road thus far against the Falcons, but they were unable to get anything moving against the tough Jaguars defense. Expect the same outcome here against another tough defense — the Broncos defense has allowed 338.6 total yards per game this season 21.2 points per game. This is a top ten defense that will match every play the Titans have. Do not expect a blow out here as both teams are going to be playing rough and tough defensive style in this matchup. With the spread of less than three points, this is the perfect time to lay with the Broncos as they win by a field goal in the closing seconds. The Titans are 1-5 ATS in their last 6 meetings as well as 1-4 ATS in their last 5 games in Week 6. Broncos is the play here.

Over Under Pick

As stated above, the Broncos and Titans defenses are some of the best in the league, in the top ten for points per game allowed and yards per play. This is going to be a low-scoring game with both teams having trouble moving the ball down the field, especially the Titans who take on a Broncos defense that is allowing 0.2 touchdowns in the red zone per game. Denver tightens up near the goal line and will cause problems for the Titans. The Under is 9-1-1 in Broncos last 11 games following a straight-up win as well as 8-1 in Broncos last 9 home games. The Under is another great play for Sunday.

Sun, Oct 13th - 4:25pm ET:
Dallas Cowboys @ New York Jets

Dallas Cowboys
New York Jets
DAL Cowboys -8.5 Point Spread
-111
Over 43.5 Game Totals
-111

Against The Spread Pick

Which Dallas Cowboys team will show up this Sunday? Will it be the impressive Cowboys team that started out 3-0 with Dak Prescott running wild throwing touchdowns left and right? Or will it be the Cowboys who have lost two straight games against the New Orleans Saints (4-1) and Packers (4-1), two teams that lead their divisions? Long story short, it does not matter because the New York Jets are one of the worst teams in the league. Even at their worst, the Cowboys can beat down the Jets with ease. The Jets have played 14 quarters this season and only have one offensive touchdown. It does not matter that much that Sam Darnold is back with the team as he has not practiced properly for over four weeks. The Jets are 1-8 straight up in their last nine against NFC opponents as well as 1-4 ATS in their last five home games against Dallas. The Cowboys are going to win this game BIG.

Over Under Pick

This is a perfect opportunity for Prescott and the Cowboys to get back on track and it starts with the offense. Dallas has seen the total go over the number in seven of its last 10, while New York has seen the total eclipse the posted number in nine of its last 14 as a home dog. This number is super low and with Darnold back the Jets will at least have more chance of scoring a second offensive touchdown this season. With Dallas allowing five yards per play, expect the Jets to move the ball early in this game. The Over is also 5-2 in Jets last 7 games in October as this has the perfect play for this game to be high-scoring. Take the Over here everybody.

Sun, Oct 13th - 8:20pm ET:
Pittsburgh Steelers @ Los Angeles Chargers

Pittsburgh Steelers
Los Angeles Chargers
LA Chargers -6.5 Point Spread
-111
Under 41.0 Game Totals
-111

Against the Spread Pick

The Los Angeles Chargers will host the Pittsburgh Steelers for Sunday Night Football. Not only will the Steelers be without Ben Roethlisberger, they’ll also be without the man tapped to replace him in Mason Rudolph. Undrafted rookie Devlin Hodges will make his first career start here, and I expect it to be a disaster. Hodges went to Samford and didn’t even play D-I football, and started this summer off as a camp arm. The Chargers are reeling after they got upset by the Broncos, and they should come out angry here. At 1-4 and on their third-string quarterback, the Steelers know their season is over. They’re coming off an overtime loss, and I expect them to look sluggish here. Hodges is going up against a talented defensive front led by Joey Bosa, who should make life miserable for him. Philip Rivers is coming off one of his worst games in years, and I expect him to bounce back here. Los Angeles will easily win this one by at least a touchdown.

Over Under Pick

The under also makes a lot of sense here. Hodges is getting thrown to the wolves here, and I don’t expect much at all from him. Even with all their injuries, the Chargers still have a very talented defense. Casey Hayward, Desmond King, and Michael Davis are one of the best cornerback trios in the league, and Bosa should provide plenty of pressure up front. Los Angeles has a terrible offensive line that can’t protect Rivers, so I don’t expect them to look like an offensive juggernaut here either.

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