Kansas City Royals vs Los Angeles Angels Prediction, Odds and Picks for Wednesday, 09/24/25

The Angels continue to limp through the final month of the season. Los Angeles has now dropped 10 of its last 11 games, including Tuesday night’s series opener against the Royals by a score of 8-4. Yusei Kikuchi is slated to take the mound for Los Angeles, and the Angels have dropped each of his last 5 starts. However, Kikuchi has been much better at home this season than on the road. His ERA sits at 3.00 at home and goes to 5.04 on the road. He’ll be at home for this one, and the Royals rank 26th in the league with a modest .660 OPS against lefties on the year. Kikuchi should be able to limit the damage from Kansas City’s lineup.

On the other side, Stephen Kolek has been great for the Royals since coming to Kansas City from the Padres in August. In 4 outings with his new team, Kolek owns a strong 1.67 ERA and 0.67 WHIP through 27.0 innings of work. He will face a Los Angeles offense that is reeling, so he could be in a solid spot to keep things rolling. Following a high-scoring game last night, look for Wednesday’s contest to be more on the lower-scoring side. Consider the under.

Royals vs Angels prediction: Under 8.5 (-125) available at time of publishing. Playable at that number.

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