Los Angeles Dodgers vs Arizona Diamondbacks Prediction, Odds and Picks for Today, 09/25/25

In this game, we will see the Los Angeles Dodgers take on the Arizona Diamondbacks. These teams have split the last 2 nights. On the mound today, we have Yoshinobu Yamamoto of the Dodgers and Zac Gallen of the Diamondbacks. Yamamoto has looked incredible in his last 4 starts. Through those starts he has pitched 28 innings giving up just 7 hits and 3 earned runs. Yamamoto has also faced the Diamondbacks three times this season. The most recent 2 have been great with him giving up just 1 run in 14 innings pitched. In his first meeting, he gave up 6 hits and 5 earned runs in 5 innings pitched. I suspect we may see numbers closer to the first meeting today as the Diamondbacks are batting .291 over the last 5 games. Additionally, the Dodgers bullpen has been struggling in recent games.

For the Diamondbacks, Gallen will take the hill. Gallen had a rough start to the season but has improved significantly since the start of August. Since then, he has pitched 60.2 innings giving up 44 hits and 19 earned runs. Additionally, he has given up 1 or fewer runs in 4 of his last 6 starts. The good news for Gallen is that the Dodgers are only batting .226 over the past 6 games. He also faced the Dodgers recently where he pitched 6 innings giving up just 2 hits and no earned runs. Between these 2 pitchers it should be a great matchup. Outside of the starters, the Dodgers bullpen has tried to lose the game for them the past 2 nights, though they were only successful once. The Dodgers pen is so shaky that it is hard to trust them against a Diamondbacks team that is so close to the final playoff spot. All in all, I am going to trust the Diamondbacks to hit the ball well and get the win they are looking for.

Dodgers vs. Diamondbacks Prediction: Diamondbacks ML (+135) available at the time of publishing. Playable at that number.