Tampa Bay Rays vs Baltimore Orioles Prediction, Odds and Picks for Wednesday, 09/24/25

After the Orioles took Tuesday’s series opener 6-0, the Orioles and Rays are set for a Wednesday night battle at Camden Yards. The pitching matchup will feature Tampa Bay’s Shane Baz against Baltimore’s Tyler Wells. Baz has struggled on the road lately, allowing 16 earned runs over his last 4 road starts and 19.1 innings of work. The Baltimore offense has been steady against Tampa Bay pitching this season, scoring at least 5 runs in 6 of their last 10 meetings. Expect Baz’s road woes to continue.

Wells will be making just his fourth start of the season in this one. He is coming off a pair of strong outings against the Pirates and White Sox, but they are 2 of the worst offenses in all of baseball — ranking 30th and 28th, respectively, in total runs scored this season. Tampa Bay is more at the middle of the pack and should present a tougher challenge for Wells. Furthermore, the bullpen behind him ranks 26th in the league with a 4.64 ERA. All in all, while neither offense has been elite this season, both lineups could have the edge in this matchup. Look to the over.

Rays vs Orioles prediction: Over 8.5 (-110) available at time of publishing. Playable at that number.

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