49ers vs Colts Anytime Touchdown Scorer Predictions for MNF Week 16

San Francisco 49ers tight end George Kittle (85) celebrates after scoring a touchdown against the Seattle Seahawks in the fourth quarter at Levi's Stadium.
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44-year-old Philip Rivers will make his home debut off the couch for the Colts against a surging 49ers team, winners of 4 straight and still alive for the #1 seed in the NFC. Let’s dive into our 49ers vs Colts anytime TD scorer best bets for MNF. You can also find out our NFL picks for every game throughout the season — including pro NFL bettor Chris Farley’s 49ers vs Colts MNF best bet.

49ers vs Colts anytime touchdown scorer best bet: George Kittle (+125)

Odds available at DraftKings Sportsbook at time of publishing

A healthy George Kittle is good for football. After missing 5 of the first 6 weeks of the season, Kittle has put together 8 straight games of 4+ receptions, while finding the endzone 5 times. Christian McCaffrey overshadows Kittle in the passing game, but Kittle’s 26.5% target share since Week 10 is an indication that Brock Purdy has no problem spreading the ball towards Kittle’s direction, especially against a lackluster Colts passing defense.

49ers vs Colts anytime touchdown scorer pick: Tyler Warren (+280)

Odds available at BetMGM Sportsbook at time of publishing

Let’s back the other tight star in 49ers vs Colts for our 2nd TD scorer. Tyler Warren was off to a strong start to the season, but his play has declined in recent weeks. Philip Rivers is most definitely not the answer for Warren to have success on Monday Night, but the Colts use him in a variety of ways, especially down in the redzone. If the Colts find themselves in a 4th and short inside the 5-yard line, look for Warren to tush push his way in or have Rivers find him over the top of the defense.
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