The first 1:00 pm ET and 4:25 pm ET windows of the NFL season present bettors with 12 games to attack on Sunday, September 7. And what better way to celebrate the first mega-slate of the 2025 campaign than with some wagers on players to find the end zone? Let’s dive into our NFL Week 1 anytime TD scorer best bets, while you can also find out our experts’ NFL picks for EVERY game in Week 1.
Cardinals vs Saints anytime touchdown scorer pick: Trey McBride (+200)
Line available at DraftKings Sportsbook at time of publishing.
The talk about Trey McBride last season wasn’t about his elite volume or extremely high floor, but his failure to find the end zone. McBride scored just 2 touchdowns in 2024 — both coming in Week 17 and 18. Yet he caught 111 balls on 147 targets, including 20 targets in the red zone – 3rd-most amongst tight ends. Against the woeful New Orleans Saints defense on Sunday, expect McBride to showcase why he deserved the contract he signed to make him the highest-paid tight end in NFL history.
Find out ThatGuyBets’ best NFL Week 1 player prop bets, targeting Jonathan Taylor and Tyler Allgeier!
Buccaneers vs Falcons anytime touchdown scorer pick: Drake London (+140)
Line available at BetMGM Sportsbook at time of publishing.
Nobody enjoyed the emergence of quarterback Michael Penix Jr. to conclude the Falcons’ regular season more than Drake London. Penix and London connected on 22 passes on 352 yards — leading the NFL in receiving yards during weeks 16-18. Penix targeted London a league-leading 39.8% of the time on his dropbacks. All headlines will be on Bijan Robinson cementing himself as a top-3 running back in the league, but London is not short of joining the top of the wide receiver list. Back him to find the end zone in Week 1 at +140 on BetMGM.
Read our full Buccaneers vs Falcons predictions, which includes a 5-star best bet!
49ers vs Seahawks anytime touchdown scorer pick: Ricky Pearsall (+190)
Line available at FanDuel Sportsbook at time of publishing.
Let’s jump to the 4:25 pm ET window for our 3rd and final Week 1 anytime TD scorer bet. A whirlwind of a rookie season for Ricky Pearsall included a gunshot wound that held him out for the first month and a half of the season, but concluded with 200+ receiving yards and 2 touchdowns in the final 2 weeks. He connected with quarterback Brock Purdy late in the season, which translated into this year’s preseason. During their preseason game against the Raiders, Purdy connected with Pearsall three times for 42 yards on just 1 drive. With Deebo Samuel now in Washington and question marks surrounding Jauan Jennings, who is expected to play Week 1, I’m backing Pearsall to score a touchdown in Week 1 at +190 odds on FanDuel.
Check out our 49ers vs Seahawks picks for Sunday’s game
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