Josh Gayle
The end of the 2025 MLB regular season is in sight with just a couple of weeks to go until the Wild Card gets underway. We still have a bunch of teams battling it out to reach the Wild Card, making every matchup down the home stretch that bit more important. Among tonight’s clashes are Padres vs Mets on TBS, with New York looking to get back on track with their own postseason berth in jeopardy, along with Rangers vs Astros, Giants vs Diamondbacks and Phillies vs Dodgers. However, for my YRFI/NRFI/NRSI best bet on Tuesday, September 16, we’re heading to Comerica Park for Guardians vs Tigers. Let’s break down why, while you can also get our expert MLB picks for EVERY GAME today.
YRFI/NRFI best bet: Guardians vs Tigers – NRSI (-132)
Odds available at FanDuel Sportsbook at time of publishing.
This game is a sneaky good pitching matchup in a pitcher-friendly park. Casey Mize has taken care of Cleveland so far in 2025, pitching with a 0.75 ERA over 12 innings against them this year. JRam is a lifetime 4-7 against him with 2 HR so I like targeting the 2nd inning in this one. On the flip side, we have Joey Cantillo, who has been pitching some outstanding baseball as of late. He has only allowed 3 runs over his last 24.2 innings pitched. In the last 4 starts, he has allowed just 1 run or less. He has really emerged with a great August and even more outstanding September. I like the 2nd inning to remain scoreless here as the MLB season creeps closer to the end. Let’s roll!
Don’t miss out on today’s MLB best bets, with our red-hot experts on a HUGE 34-16 run!
