Andrew Wilsher
Week 8 of the 2025 NFL season is on the horizon, and we have plenty of great matchups to get excited for. The Giants travel to Philadelphia to take on the Eagles as they look to do the double over their divisional rivals and bounce back from last Sunday’s heartbreaking loss to the Broncos. Plus, Lamar Jackson looks set to return for Baltimore and get the Ravens’ season back on track as they host the Bears. We also have the 49ers visiting the Texans while the Cowboys take on Denver. Make sure you check out our NFL predictions as we add our picks on the side and total for every game throughout the week. But for now, let’s break down the NFL Week 8 opening lines and give our best early bet to make.
NFL Week 8 opening lines and odds
Odds available at bet365 at time of publishing
- Vikings +3 (-115) vs Chargers -3 (-105) — Thursday Night Football
- Bills -7.5 (-110) vs Panthers +7.5 (-110)
- Bears +7 (-115) vs Ravens -7 (-105)
- Browns +7 (-110) vs Patriots -7 (-110)
- Dolphins +7.5 (-110) vs Falcons -7.5 (-110)
- Giants +7 (-110) vs Eagles -7 (-110)
- Jets +6.5 (-110) vs Bengals -6.5 (-110)
- 49ers +1.5 (-110) vs Texans -1.5 (-110)
- Buccaneers -6.5 (-105) vs Saints +6.5 (-115)
- Cowboys +3 (-110) vs Broncos -3 (-110)
- Titans +14 (-110) vs Colts -14 (-110)
- Packers -3 (-120) vs Steelers +3 (+100) — Sunday Night Football
- Commanders +10 (-110) vs Chiefs -10 (-110) — Monday Night Football
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Best bet for NFL Week 8: Houston Texans ML over San Francisco 49ers (-125)
Odds available at bet365 at time of publishing
I’m jumping on this now before the Texans play the Seahawks on MNF. That result could of course sway this number in either direction, but I’ve got a feeling we see Houston deliver a strong performance and for this number to shorten regardless. The Texans started the season with a dismal 0-3 record, but those defeats came against some strong Rams, Bucs and Jaguars teams. They have since pulverized both the Titans and Jackson-less Ravens by a combined 70-10 score. Houston’s defense is holding up exceptionally well, and now that their offense is starting to show life, this team looks capable of going on a serious run.
The 49ers earned a big victory over the Falcons on SNF last week to move to 5-2 behind a big game from Christian McCaffrey, but I’m still not sold on this team. They are still dealing with a laundry list of injuries and while Mac Jones has been a good game manager, I don’t hold out much hope of him causing problems for a Texans defense that looks to be among the best units in the NFL. Given Houston is also at home, this game shouldn’t be close to a pick’em in my opinion, and I like the Texans to prevail at anything up to a field goal.
Don’t miss our NFL picks for every game in Week 8! Our experts have an 117-94-1 record this season for +30.7 units!
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