Prop Holliday - Bobby Stanley
Thursday Night Football in Week 5 gives us an NFC West showdown between the San Francisco 49ers (+7) and the Los Angeles Rams (total 46.5). The 49ers limp into this game with injuries across the board, the key ones being QB Brock Purdy, WR Ricky Pearsall, WR Jauan Jennings and DE Yetur Gross-Matos. All indications are that Mac Jones will be under center on TNF, which would bode well for Rams bettors. Los Angeles boasts the same 3-1 record but has their first divisional game of the season. This matchup historically has favored San Francisco, but the Rams appear to be the better (and healthier) team so far in 2025. Let’s get into my best 49ers vs Rams player prop bet, while you can also check out our NFL picks for every game this week, with our experts boasting a 73-54-1 record this season for +37.1 units!
Find out Chris Farley’s 49ers vs Rams best bets on the side and total for TNF
Best 49ers vs Rams player prop bet: Kyren Williams (LAR) under 17.5 rush attempts (-130)
Odds available at BetMGM at time of publishing. 1.25u. Playable at 16.5 for 1u.
This line comes on the back of a dominant Kyren Williams performance in Week 4 where the Rams took down the Indianapolis Colts in a shootout; Williams took 2 carries on the last series to get him to 13. He’s gone over this line in 2 of 4 games this season (3 of 4 at 16.5), but what I noticed last week is McVay’s insistence on getting Corum entrenched into the rotation. He’s on record stating he wants a 65/35 split and after the Colts win, he doubled down stating he will not ride the hot hand since the team is at its best when both backs are involved.
Corum has seen his snaps grow in each of the last 3 weeks, and in order for the 49ers to have a shot at the upset, they will need to control the clock and keep Stafford & company on the sidelines. This number is just too high for me given Corum’s cemented role and the fact that Williams is coming off his lowest snap count of the season. San Francisco ranks 31st in pressure rate through 4 weeks of the season, which should give McVay more reason to utilize the passing game to make a statement in primetime.
Find out JutPicks’ 49ers vs Rams touchdown scorer best bets for TNF, along with our 49ers vs Rams Same Game Parlay picks at +465 odds!
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