The Colts enter this battle in a desperate mood and they’re getting over a touchdown of points to boot. There is a world where the new-look Chiefs pull away, but we also can’t handicap this matchup based on a one-game sample size, either. Buy low on Indianapolis and sell high on Kansas City.

Shane Steichen specializes in offense and his group left much to be desired after a 23-point output (and just 251 yards) last Sunday. We doubt the Colts will depend on their defense to correct their woes, while the Chiefs offense should be on fire once again behind Patrick Mahomes and Kenneth Walker.

After beating the Cowboys in their opener, the Giants now need to refocus and travel across the country to face an angry Matthew Stafford and company. On paper, the Rams still own one of the most impressive skill groups in the NFL. We like regression to swing this in favor of LA.

The Giants’ defense looked good against Dallas, but they don’t know the Rams like the 49ers do. Nor does John Harbaugh. Expect Los Angeles to score immediately, which means the Giants will be chasing. If New York can get to 20, this total should soar over 50.