Detroit Tigers vs Cleveland Guardians Prediction, Odds and Picks for Wednesday, 09/24/25

The Detroit Tigers are skidding hard and they have frittered away a gigantic lead in the American League Central Division. Detroit entered this series with a slim 1-game lead in the division, but Cleveland picked up a 5-2 win on Tuesday — dealing the Tigers a seventh consecutive loss. The Guardians have clinched the season series, so if there is a tie atop the division at season’s end, Cleveland owns the tiebreaker. Detroit led by 14 games in this division on July 9, but with 5 games left in the regular season, it’s now a dead heat.

The Tigers turn to RHP Jack Flaherty to try and turn things around. Flaherty has compiled a dismal 8-14 record, 4.60 ERA and 1.28 WHIP across 156.2 innings in 30 starts. He is an innings eater, but he isn’t terribly effective. In his past 7 starts he has a 4.71 ERA with 11 walks in 36.1 innings, and he lost his last start in Detroit last Wednesday. On the road, Flaherty is even worse — going 3-6 with a 5.20 ERA and 1.38 WHIP across 64.0 innings in 13 starts. The Guardians hand the ball to RHP Tanner Bibee, looking to grab the division lead. He is 2-0 with a 0.69 ERA in 2 starts against the Tigers, allowing just a single run and seven hits in 13 IP against Detroit this season, and the Tigers are hitting just .152 against him. Cleveland looks like a strong play yet again.

Tigers vs Guardians prediction: Cleveland ML (-125) available at time of publishing. Playable to -140.

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