49ers vs Seahawks Picks, Props & Parlay for NFL Divisional Round Saturday

Seattle Seahawks quarterback Sam Darnold (14) throws the ball during the first quarter against New Orleans Saints at Lumen Field.

Andrew Wilsher

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Managing Editor of Pickswise. Born and raised in jolly old London, England, with an undying love for the NFL, NBA, soccer and horse racing. A big-time sports bettor who loves futures markets and backing underdogs. Long-suffering New York Jets fan. For Andrew Wilsher media enquiries, please email contact@pickswise.com.

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49ers vs Seahawks predictions & NFL Divisional Round picks

Chris Farley’s 49ers vs Seahawks spread prediction: Seahawks -7.5 (-115)

If you watched last week‘s game between the 49ers and the Eagles, it wasn’t completely surprising to see the result. Since Brock Purdy has returned as the 49ers’ starting quarterback, their offense has been humming, right up there with the best passing operations in the NFL. Despite throwing 2 interceptions, Purdy was ice cold when it mattered most, going 6-11 on third downs and engineering 13 fourth-quarter points against one of the NFL’s best defenses. Perhaps most impressive about San Francisco’s production was that they only possessed the ball for 24 minutes.

The Niners defense played well, but some of that is more on Philadelphia’s lackluster offense. The Eagles’ offensive operation has been pedestrian for most of the season, so it wasn’t surprising to see them stumbling through the second half, earning just 6 points and 104 yards in the final 2 quarters. Credit should be given to Robert Saleh and his roster, but we’re also not sure if it’s sustainable. That’s particularly true this weekend.

The Seahawks enter the divisional round off extended rest, and they will host their first playoff game Saturday night. The dominance of their defense has been well documented, completely obliterating San Francisco in their last matchup in Week 18 (they held Brock Purdy and company to just 3 points and 173 yards). Offensively, they left plenty on the field, garnering just 13 points themselves. Most impressively, they ran for 180 yards on 4.6 yards per carry, and completely controlled time of possession because of it (37:48 to 22:12). Their passing attack wasn’t that explosive, but Sam Darnold was efficient (20-26, 198 yards) and the game never felt within reach for the visiting Niners.

While the rematch might not look the exact same, we are expecting a similar result. San Francisco’s impressive victory last Sunday came at the cost of George Kittle, their all-pro tight end who’s as crucial in blocking as he is in the pass catcher. He tore his Achilles and will be out for the remainder of the season, yet another big loss to a roster that’s been severely beaten up this year. Add to the fact that San Francisco will only have 6 days to prepare for battle after a very physical matchup in the wildcard round and it’s hard not to imagine a Seattle blowout.

Chris Farley’s 49ers vs Seahawks best bet: Under 45.5 (-110)

The late game on Saturday presents another dead total, resting right under key numbers 46 and 47. In general, this means markets and its constituent bettors think there’s a reasonable chance for a higher-scoring contest, but not a great enough chance that it should come close to 50. In the case of this big NFC matchup, there is certainly reason to believe it will get nowhere near those numbers.

Seattle’s defense had a serious edge in their last battle, which was only 2 weeks ago. Swarming and suffocating throughout the contest, the Niners only made it into the red-zone on one occasion, failing to score a touchdown. Brock Purdy, who has sneaky elusiveness and savvy in the pocket, was sacked 3 times, hit another three times and limited to a 22.8 QBR. He also threw an interception, which has become a trend in 2025 (12 interceptions in 10 games this season, which matches his total in 15 starts in 2024). The Seahawks also held the 49ers to just 53 total rushing yards, a truly shocking mark considering Kyle Shanahan’s emphasis on the run game.

This season the 49ers are 30th in yards per rush (3.7), so we doubt the Seahawks will have any issues limiting them once again. That means the onus of the Niners’ offense will rest solely on Purdy’s shoulders. The former Iowa State QB has earned some trust, but this situation is different. No George Kittle means a major piece of their offense is missing. Add a raucous Seattle crowd and the fact that Purdy is facing the 2nd-best defense in the NFL (according to advanced EPA metrics), and we don’t feel great about his chances. In short, based on everything we’ve seen from both programs this season, it would take an exceedingly masterful game-plan and an all-world performance by San Francisco’s role players to reach 20-points or better.

Two weeks ago the San Francisco defense made another valiant effort to stymie Seattle’s production. Considering their injuries and many shortcomings throughout this season (they’re 24th in total defensive EPA), we don’t exactly have faith that they can keep their current overperformance going. What we do have faith in is that Robert Saleh is an excellent defensive coach who gets the most out of his players, regardless of their history or prowess. Considering the many other factors that support a low-scoring affair, that should be plenty to keep this total closer to 40 than 45.

Read NFL pro bettor Chris Farley’s full analysis for his 49ers vs Seahawks predictions, where he has hit 9 of his last 12 picks!

49ers vs Seahawks MNF player prop bets

Prop Holliday’s best 49ers vs Seahawks player prop pick: Kendrick Bourne (SF) over 5.5 receiving yards (-110)

George Kittle going down last week was just another deathblow to this 49ers squad that’s seen a season riddled with them. HC Kyle Shanahan is a master at piecing things together with his schemes, which is why finding player props for the 49ers can be so profitable if you hit on the right skill positions player.

This week, I’m going with Kendrick Bourne to step up and we’re getting essentially a one-reception yardage line for him. In the games that just Kittle missed this season, Bourne was 3rd on the team in targets overall and 3rd in receptions vs zone defense behind CMC and Jake Tonges. Most importantly, in the games that Kittle missed, Bourne tied for first with targets out of the slot (13 in games). Last week, Bourne played 37% of snaps with Pearsall out and although Pearsall is returning, I still expect Bourne to see 30-40% of snaps.

Prop Holliday’s 49ers vs Seahawks player prop bet: AJ Barner (SEA) 25+ receiving yards & Christian McCaffrey 6+ receptions (+135)

I’ve had some success with these alt-line SGP’s this season in my articles, and going back to it here for Saturday night’s showdown. On the McCaffrey side of this, his role is going to be RB1/WR1 and game plan shaped around him as much as possible. His median receptions output is 6, so with this line at 6.5, I don’t feel comfortable going to that 7 number, but the Seahawks rank 32nd in targets allowed to RB’s against easily the best receiving RB in football.

On the Barner side of this SGP, he ranks 2nd in receiving yards when lined up inline against a SF defense ranked 28th in receiving yards lined up inline according to PFF. His median yardage output this season is 27 yard and his line is at 30.5-33.5 so we bring this down to 25 feeling comfortable in the matchup.

49ers vs Seahawks TD scorer best bet: Jaxon Smith-Njigba anytime touchdown scorer (+100)

Jaxon Smith-Njigba will be turning in some hardware for his career season. He’s -1250 to win Offensive Player of the Year after reeling in 119 catches on 1,793 yards during the regular season. His 36% team target share led the NFL, and is an encouraging sign that Sam Darnold will be looking his way on Saturday Night. Though he failed to score versus the 49ers during the regular season, he’s still our top 49ers vs Seahawks TD scorer best bet.

49ers vs Seahawks TD scorer prediction: Brock Purdy anytime touchdown scorer (+700)

Brock Purdy lost one of the best pass-catchers in the league last week in George Kittle, who tore his achilles. His pass-catchers on the outside will now have a much bigger role against a Seahawks secondary that ranks in the top 5 in air yards on completions and redzone TD percentage at 50%.

Purdy is no stranger to using his legs. Since returning to full health in Week 11, Purdy has run in three touchdowns on three carries inside the 20, while throwing 10 touchdowns and zero interceptions. With Christian McCaffrey having all the attention on him, and Kittle sidelined, look for Purdy to try his luck finding the endzone himself.

Now check out the rest of JutPicks’ 49ers vs Seahawks touchdown scorer best bets

San Francisco 49ers vs Seattle Seahawks parlay

After cashing our Bills vs Jags SGP at +900 last week, make sure you check out our 49ers vs Seahawks parlay picks at +490 odds for tonight’s matchup

49ers vs Seahawks SGP pick: 49ers +7.5 alternate spread over Seahawks (-122)

While this isn’t my favorite play on the board on Saturday, it’s hard to see the Seahawks winning by the necessary margin in this game considering how Seattle’s offense fared against playoff teams this season. We know that the Seahawks defense is outstanding and that should be enough to carry them to a victory at home against a banged-up San Francisco team, but it’s hard to trust Sam Darnold in a spot where he has struggled mightily in the not-so-recent pass. Ultimately, I have enough faith in DC Robert Saleh and the 49ers’ defensive staff to do just enough to keep this game very low-scoring. It might only take 1 or 2 successful scoring drives from Brock Purdy to keep this game within a touchdown.

49ers vs Seahawks SGP pick: Under 45.5 (-118)

The market has come down a bit on this total, but it’s still hard to get there with an over at the current number. Seattle’s elite defense (2nd in EPA per play) swarmed and suffocated the 49ers offense a few weeks ago, and that was not factoring in the injury to George Kittle, which is obviously a major blow for a San Francisco team that doesn’t have many paths to score points beyond whatever Kyle Shanahan can draw up. On the other side, we can expect the Seahawks to be very cautious with Sam Darnold in this game given his recent playoff history — especially if Seattle is able to get a lead by the second half. Look for both teams to run the ball and emphasize winning the field possession battle in a game that could be a grind-it-out affair.

49ers vs Seahawks SGP pick: Christian McCaffrey Over 53.5 receiving yards (-115)

It’s no secret that Christian McCaffrey has been a workhouse for the 49ers all season long, and there’s no reason for that to change on Saturday, especially when considering the situation at hand for the 49ers on offense. Shanahan loves to get McCaffrey the ball, and the 49ers bellcow will likely have to shoulder the load as a receiver out of the backfield given the shorthanded nature of this San Francisco offense. McCaffrey racked up 6 receptions for 66 yards against the Eagles a week ago, and he should be able to replicate that performance in a do-or-die game this week. Regardless of how the game turns out, Saturday’s game should be a showcase for the 49ers running back to put up numbers against a familiar foe.