Week 12 of the 2025 NFL campaign wraps up with a Monday Night Football showdown between the Carolina Panthers and San Francisco 49ers. Both teams are in the mix for a wild card in the NFC. Carolina is sporting a 6-5 record, while San Francisco is 7-4.
Here is my Same Game Parlay for the festivities, which get underway at 8:15 pm ET on ESPN. Also be sure to check out our full Panthers vs 49ers predictions.
Panthers vs 49ers Over 49.5 (-110)
Bryce Young to record 250+ passing yards (+240)
Christian McCaffrey to record 50+ receiving yards (+120)
Parlay odds: +750
Part of the value in a Same Game Parlay, of course, is that all of its components can be correlated if you so choose. That is the entire plan here, as Carolina quarterback Bryce Young and San Francisco running back Christian McCaffrey racking up their fair share of yards would both obviously work well with the over. Let’s break down each of the 3 legs.
Panthers vs 49ers Over 49.5 (-110)
Brock Purdy returned from his latest injury in Week 11 and looked great, leading San Francisco to a 41-22 rout of Arizona. Purdy completed 19 of 26 passes for 200 yards and three touchdowns. More success should be in store for an offense that is healthier than it has been all season long. Tight end George Kittle is back in action along with receivers Ricky Pearsall and Jauan Jennings. Unfortunately for the 49ers’ defense, it is a banged-up unit that is without Nick Bosa and Fred Warner for the rest of the year. By EPA metrics, the Niners are #31 league wide in defensive success rate. They have given up 114 points over their past 4 contests. The Panthers’ offense may not be anything special, but they should be playing with some confidence following last weekend’s stellar performance against the Falcons.
Bryce Young to record 250+ passing yards (+240)
If only Young could face the Falcons every game… The former #1 overall pick torched Atlanta for 448 yards and 3 touchdowns during last week’s 30-27 overtime victory. That was preceded by a 251-yard, 3-touchdown effort in the 2024 finale against the same opponent. It’s worth noting that the Falcons were the #1 passing defense in the entire league heading into last week, so Young should also be able to find success against other teams. That includes the 49ers, who are second-to-last in passing defense at 254.5 yards per game allowed. They are giving up the eighth-most yards per attempt (7.6). As a considerable underdog, Carolina will likely be playing from behind early and often – resulting in a whole lot of passes thrown by Young.
Christian McCaffrey to record 50+ receiving yards (+120)
McCaffrey is the best pass-catching running back in the NFL. The Stanford product has already hauled in 74 passes on 96 targets for 732 yards and 5 touchdowns this season. He did not really miss a beat with Mac Jones under center, but his rapport with Purdy is even better. In the 3 games started by Purdy this year, McCaffrey is averaging 67 receiving yards and he has found the endzone twice via the air. Another productive outing should be in the cards against Carolina. The Panthers have allowed the fourth-most receptions to opposing RBs in 2025. Count on McCaffrey victimizing his former team to a significant extent on Monday Night Football.
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