College Football Week 12 Betting Guide: CFB Expert picks for Saturday, November 15

Andrew Wilsher

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Managing Editor of Pickswise. Born and raised in jolly old London, England, with an undying love for the NFL, NBA, soccer and horse racing. A big-time sports bettor who loves futures markets and backing underdogs. Long-suffering New York Jets fan. For Andrew Wilsher media enquiries, please email contact@pickswise.com.

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Updated: 19:56 PM ET November 14, 2025

College football Saturday is upon us! We have another huge slate of great CFB matchups to sink our teeth into on Saturday, November 15, across all the Power Conferences and Group of 5. With just 3 more Saturdays left of the regular season before Championship Week and Bowl season, we need to enjoy the football feast while we can. Among the big matchups this week are Oklahoma’s visit to Alabama, Texas’ trip to Georgia and Iowa vs USC.

Pickswise’s expert CFB handicappers have been hot this season, so let’s see if we can keep that up here! You can find out all of our NCAAF picks and CFB predictions for more than 30 games on Saturday, plus we have our college football expert’s best bets of the day, along with our parlays and Same Game Parlay picks to help you bet better across all of the action.

Let’s dive in!

College football Saturday best bets for Week 12

CFB Saturday best bets — college football expert Caleb Wilfinger’s top 3 picks for Saturday’s Week 12 action

College football Week 12 parlays

Go for the big payday on Saturday with our handicappers’ best CFB parlays for the day:

College football Saturday parlay — see our expert’s 3-leg parlay at +1180 odds!
Oklahoma vs Alabama Same Game Parlay — get hyped for this huge SEC clash with our expert’s SGP

College football Week 12 picks

Below, you’ll find our betting previews and NCAAF predictions for all the biggest games in Week 12. However, you can also check out our expert CFB picks for more than 30 of Saturday’s matchups!