College Football Week 14 opening lines, odds and best bet: Ohio State Buckeyes seek revenge in The Game

Ohio State Buckeyes celebrate with fans after defeating Michigan State Spartans at Spartan Stadium on Saturday.
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Sam Avellone

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Long-time suffering Browns fan born and raised in the greater Cleveland, Ohio area who now resides in SEC country. University of South Carolina alum. Sports handicapper for close to 10 years with a primary focus on NCAAB while enjoying NFL, PGA, NCAAF, NBA, and Soccer. For Sam Avellone media enquiries, please email contact@pickswise.com.
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This is it! It’s the final week of the college football regular season. Sure, it feels somewhat bittersweet. However, the inaugural 12-team College Football Playoff is right around the corner now, which is sure to provide us with the most entertaining postseason we have ever seen in this sport. As we have done every week, let’s take a moment to analyze the opening lines and odds for college football Week 14, and then I will pick my favorite of the bunch to bet right now. Arizona State got us to the window last week, which improved our record to 9-3 on our opening line best bets – a win rate of 75%! Make sure to check Pickswise daily for college football picks and CFB predictions for the rest of the season, including Week 14, bowl season and the College Football Playoff.

College football Week 14 opening lines and odds

Odds courtesy of Bet365 and available at time of publishing.

  • Tulane -14 (-110) vs Memphis – Thursday, November 28th
  • Bowling Green -3 (-105) vs Miami (OH) – Friday, November 29th
  • Wisconsin -2 (-110) vs Minnesota – Friday, November 29th
  • Colorado -16.5 (-110) vs Oklahoma State – Friday, November 29th
  • Boise State -19.5 (-110) vs Oregon State – Friday, November 29th
  • Liberty -2.5 (-110) @ Sam Houston State – Friday, November 29th
  • Colorado State -6 (-110) vs Utah State – Friday, November 29th
  • Georgia -19.5 (-110) vs Georgia Tech – Friday, November 29th
  • Iowa -5.5 (-110) vs Nebraska – Friday, November 29th
  • UCF -8 (-110) vs Utah – Friday, November 29th
  • Baylor -1.5 (-110) vs Kansas – Saturday, November 30th
  • Louisville -3.5 (-110) vs Kentucky – Saturday, November 30th
  • Ohio State -20.5 (-110) vs Michigan – Saturday, November 30th
  • Clemson -2.5 (-110) vs South Carolina – Saturday, November 30th
  • Tennessee -11 (-110) @ Vanderbilt – Saturday, November 30th
  • Army -7.5 (-110) vs UT San Antonio – Saturday, November 30th
  • Texas Tech – 3.5 (-110) vs West Virginia – Saturday, November 30th
  • Coastal Carolina -1 (-110) @ Georgia State – Saturday, November 30th
  • Arizona State -8.5 (-110) @ Arizona – Saturday, November 30th
  • Missouri -3.5 (-110) vs Arkansas – Saturday, November 30th
  • Alabama -11.5 (-110) vs Auburn – Saturday, November 30th
  • SMU -13 (-110) vs California – Saturday, November 30th
  • Penn State -24.5 (-110) vs Maryland – Saturday, November 30th
  • Miami -11 (-110) @ Syracuse – Saturday, November 30th
  • Notre Dame -7 (-110) @ USC – Saturday, November 30th
  • Western Kentucky -2 (-110) vs Jacksonville State – Saturday, November 30th
  • TCU -2.5 (-110) @ Cincinnati – Saturday, November 30th
  • LSU -6 (-110) vs Oklahoma – Saturday, November 30th
  • Indiana -28 (-110) vs Purdue – Saturday, November 30th
  • Iowa State -3 (-110) vs Kansas State – Saturday, November 30th
  • Texas -5.5 (-105) @ Texas A&M – Saturday, November 30th
  • Oregon -18.5 (-110) vs Washington – Saturday, November 30th
  • James Madison -3.5 (-110) vs Marshall – Saturday, November 30th

You can bet on EVERY college football game with Bet365, which has some of the best odds available. New to Bet365? No problem! Simple click here to join right now and you’ll receive $150 in bonus bets INSTANTLY when you make a first bet of just $5!

CFB Week 14 opening line best bet: Ohio State Buckeyes -20.5 over Michigan Wolverines (-110)

While the Wolverines had a good showing offensively last week at home against Northwestern, the Buckeyes should be a different beast this week. The Ohio State defense is the best in the country of late, ranking 1st nationally in PPA and 9th in success rate outside of garbage time since Week 8. The Buckeyes also have finished drives defensively at an elite rate in that time, as they are the only team in the country yielding less than 2 points per opposing drive inside their 40-yard line in the last 6 weeks. When their opposition reaches the red zone, the Buckeyes yield a touchdown on just 36% of appearances – also the best mark in the country this season. 

The run-heavy Wolverines will likely have difficulty even getting the ball into scoring range against this Ohio State defense. The Buckeyes are 3rd nationally in rushing yards allowed per game, and they have top-50 marks in opposing rush PPA, success rate and explosiveness allowed outside of garbage time since Week 8. The way to attack this Ohio State defense is through the air, but that’s not something Michigan’s offense has been able to do this season – as the Wolverines are 128th nationally in passing yards per game. They haven’t been any better in recent weeks either, ranking 99th in pass PPA and 131st in pass explosiveness since the middle of October.

This is a massive revenge spot for the Buckeyes, who have failed to win or cover against the Wolverines in the last 3 years. I’m expecting them to be fired up because of that, and because they need this win to ensure their rematch with Oregon in the Big Ten Championship in Indianapolis next week. I’m laying it with the Buckeyes at home in the Horseshoe.

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