Sam Avellone
And just like that, we’re into Week 6 of the college football season. Week 5 did not disappoint, as we saw multiple headline matchups come down to the wire, and we cashed our third early-week best bet in a row with the under in the Rice-Navy game. We are now 3-1 on these opening line reports this season and 14-5 dating back to last year. Let’s secure our fourth winner in a row this week.
Here are the Week 6 early-week lines and odds courtesy of bet365, capped off with my favorite bet of the bunch. Don’t forget to check out all of our NCAAF predictions throughout the week.
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College football Week 6 opening lines and odds
- Sam Houston State -2.5 (-110) @ New Mexico State – Thursday, October 2nd
- Delaware -2.5 (-110) vs Western Kentucky – Friday, October 3rd
- San Jose State -2.5 (-110) vs New Mexico – Friday, October 3rd
- BYU -19.5 (-110) vs West Virginia – Friday, October 3rd
- Michigan -17 (-110) vs Wisconsin – Saturday, October 4th
- Clemson -13.5 (-110) @ North Carolina – Saturday, October 4th
- Georgia -20.5 (-110) vs Kentucky – Saturday, October 4th
- Illinois -8.5 (-110) @ Purdue – Saturday, October 4th
- Cincinnati -2 (-110) vs Iowa State – Saturday, October 4th
- Navy -10.5 (-110) vs Air Force – Saturday, October 4th
- Baylor -6.5 (-110) vs Kansas State – Saturday, October 4th
- Pitt -6.5 (-110) vs Boston College – Saturday, October 4th
- Virginia Tech -6 (-110) vs Wake Forest – Saturday, October 4th
- Arizona -19.5 (-110) vs Oklahoma State – Saturday, October 4th
- Alabama -10.5 (-110) vs Vanderbilt – Saturday, October 4th
- Texas -7 (-110) @ Florida – Saturday, October 4th
- Notre Dame -18.5 (-110) vs Boise State – Saturday, October 4th
- Oregon State -2 (-115) @ App State – Saturday, October 4th
- Penn State -25 (-110) @ UCLA – Saturday, October 4th
- SMU -16.5 (-110) vs Syracuse – Saturday, October 4th
- Washington -5.5 (-110) vs Maryland – Saturday, October 4th
- Louisville -6.5 (-110) vs Virginia – Saturday, October 4th
- Nebraska -10.5 (-115) vs Michigan State – Saturday, October 4th
- Texas Tech -12 (-110) @ Houston – Saturday, October 4th
- Miami -5.5 (-110) @ Florida State – Saturday, October 4th
- Ohio State -24 (-110) vs Minnesota – Saturday, October 4th
- Texas A&M -14 (-115) vs Mississippi State – Saturday, October 4th
- TCU -14 (-110) vs Colorado – Saturday, October 4th
- Kansas -4 (-110) @ UCF – Saturday, October 4th
- Duke -3 (-110) @ Cal – Saturday, October 4th
Week 6 opening line CFB best bet: Louisville Cardinals -6.5 (-110) vs Virginia Cavaliers
This is a tough spot for the Cavaliers, who are riding high after a big, double-overtime home win over Florida State on Friday night. While they benefit from an extra day of rest ahead of their trip to Louisville, this is just the second time the Cavaliers will play on the road this season, and they have not had a bye week yet.
Despite the winning effort, Virginia surrendered greater than 500 yards and turned the ball over 3 times against Florida State last week. Those aren’t good traits to have when heading on the road for a conference game, especially when the opposing defense is as good as the Cardinals have been. For reference, Louisville is 6th nationally in standard downs PPA and 3rd nationally in PPA per pass allowed. Moreover, the Cardinals are very opportunistic defensively, boasting a top-40 havoc rate outside of garbage time.
After such an emotional win over Florida State, I’m banking on a hangover spot for Virginia when they hit the road for Louisville this Saturday. Let’s take a piece of this -6.5 now before it pops up to -7, though I would still play this at -7.
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