Week 16 of the 2025 NFL regular season is upon us, and it is highlighted in part by a Thursday Night Football showdown between the Los Angeles Rams and Seattle Seahawks. Both of these teams are battling for position at the top of the NFC West, and this game will go a long way into deciding which team will not only win the division, but will also be the #1 seed heading into the postseason. The first meeting between these teams came down to the wire, and it’s certainly on the board that we get another very close game in Seattle on Thursday. Here are my best TD scorer bets for TNF, and also be sure to check out our full Rams vs Seahawks predictions.
Rams anytime touchdown scorer best bet: Kyren Williams (+125)
Odds available at FanDuel Sportsbook at time of publishing.
On the Los Angeles side of things, the Rams offense has been one of the best in football all season long, and we can expect another solid showing on Thursday. Even against an excellent Seattle defense, there should be avenues for the Rams to see success on the ground and through the air. That’s where Kyren Williams comes in, as the dependable Rams running back has 10 touchdowns on the season while averaging just under 5 yards per carry in the process. Williams can also catch passes out of the backfield, which could come into play against a Seattle defense that should look to heat up Matthew Stafford and make things uncomfortable for the Rams downfield passing game. Look for Williams to find the end zone for a fourth consecutive contest on Thursday.
Seahawks anytime touchdown scorer best bet: Jaxon Smith-Njigba (+115)
Odds available at FanDuel Sportsbook at time of publishing.
You’d be hard-pressed to find a more productive receiver than Jaxon Smith-Njigba this season. The Ohio State product is playing like a first team All-Pro in 2025, and he could potentially even putting his name into the Offensive Player of the Year conversation given his performances over the past couple of months. The Seahawks top wide receiver has tallied 4 touchdowns over the last 4 weeks, and he also saw great success against the Rams a few weeks ago, a game in which he finished with 9 receptions and 105 receiving yards. We can expect his connection with Sam Darnold to be strong once again on Sunday, especially since this is a favorable matchup against a secondary that this Seattle offense should be familiar with. While this is a pretty safe pick, I can’t ignore how good Smith-Njigba has been all season long.
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