MLB Picks & Predictions for Tuesday, September 16: Guardians vs Tigers and Braves vs Nationals Best Bets

Chris Sale of the Atlanta Braves
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The week in Major League Baseball continues with a more-than-full 16-game slate on Tuesday (the Braves and Nationals are playing a doubleheader). It includes Padres vs Mets, Blue Jays vs Rays, Rangers vs Astros and Phillies vs Dodgers. The Pickswise team is on a 34-16 run in this MLB best bets series. Let’s build on that momentum and hopefully deliver some more winners today! You can also find out our expert MLB picks for every game on Tuesday, September 16.

MLB best bet: Cleveland Guardians vs Detroit Tigers Under 8 (-105)

Odds available at bet365 at time of publishing.

Neither Cleveland nor Detroit has been able to hit the baseball of late. The Guardians have scored 3 runs or fewer in 7 of their last 9 games. Within the first 9 innings, the Tigers have played 4 consecutive contests without crossing the plate more than 3 times. More of the same can be expected with Cleveland’s Joey Cantillo and Detroit’s Casey Mize on the mound. Cantillo (3.36 ERA) has allowed only 3 runs in 24.2 innings across his last 4 appearances; Mize (14-5, 3.83 ERA) has given up just 3 runs in 11.0 innings through 2 September outings.

It’s also worth noting that each team was off on Monday, so their relievers will be well rested and a full go for this contest. Detroit is in the top half of MLB in bullpen ERA, while Cleveland ranks 4th in that department. From start to finish in Tuesday’s game, runs will likely be difficult to come by.

Lock in ThatGuyBets’ MLB YRFI/NRFI best bets for tonight, targeting Guardians vs Tigers

MLB best bet: Atlanta Braves -1.5 over Washington Nationals (Game 2) (-105) 

Odds available at DraftKings Sportsbook at time of publishing.

The Braves should be in great shape to take the 2nd game of Tuesday’s doubleheader, largely because Chris Sale is toeing the rubber. Sale won the NL Cy Young Award in 2024 and if not for an injury that sent him to the 60-day IL this summer, he might have been in contention again this season. The southpaw is sporting a 2.52 ERA, 1.12 WHIP and a 141-to-28 strikeout-to-walk ratio in 107.0 innings. Sale has been pretty much unhittable dating back to May. He compiled a 1.11 ERA in May, a 0.83 ERA in June and a 2.62 ERA in his first 3 appearances since returning from his absence.

Atlanta will probably give its star pitcher plenty of run support, too. The visitors produced 11 runs in Monday’s blowout of the Nationals to begin this NL East series. That was preceded by an 8-run barrage in Sunday’s series finale against Houston. Washington is going with MacKenzie Gore, who is 5-14 with a 4.14 ERA. With a full 9 innings’ worth of at-bats guaranteed as the visiting team, Atlanta should be able to prevail by multiple runs in the nightcap of this twin bill.

Now check out our Braves vs Nationals prediction for Game 1 of their doubleheader today

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