Ricky Dimon
The week in Major League Baseball continues with a full 15-game slate on Wednesday. It includes Padres vs Mets, Blue Jays vs Rays, Rangers vs Astros and Phillies vs Dodgers. The Pickswise team is on an 35-17 run in this MLB best bets series. Let’s build on that momentum and hopefully deliver some more winners today!
Make sure you also check out our MLB picks for every game on Wednesday, September 17.
MLB best bet: San Francisco Giants vs Arizona Diamondbacks Under 9 (-105)
Odds available at DraftKings Sportsbook at time of publishing
Justin Verlander has turned back the clock since a slow start to his 2025 campaign. The 42-year-old is looking like the Verlander of old. In his last 4 appearances, his worst stat line is 2 runs allowed in 6.0 innings. His other 3 starts during this stretch resulted in a combined 18.0 innings with only 1 run given up. The right-hander is simply in dominant form heading into a matchup with the Diamondbacks, whom he has faced once before this season. On May 12, Verlander surrendered just 2 runs in 6.0 innings in a 2-1 Arizona victory.
Brandon Pfaadt is more vulnerable, but there are 2 factors working in his favor. He is pitching at home and he is going up against a San Francisco lineup that has been struggling. The righty is 9-3 with a 3.50 ERA at Chase Field; he is 4-5 with a laughable 7.29 ERA on the road. Prior to Tuesday’s contest, the Giants had scored a mere 3 total runs in their last 2 outings – including just 1 in the series opener in Arizona. This is a good spot for Pfaadt to go toe-to-toe with Verlander in a pitchers’ duel.
MLB best bet: Atlanta Braves ML over Washington Nationals (-152)
Odds available at FanDuel Sportsbook at time of publishing
His most recent effort notwithstanding, Hurston Waldrep generally gives Atlanta a great chance to win every time he takes the mound. In his first 7 starts of the 2025 campaign, Waldrep did not give up more than 2 runs a single time – and he held the opposition to 1 run or fewer on 6 of those occasions. The 23-year-old boasts an amazing 1.19 ERA and .207 opponent batting average in 4 appearances.
Washington is countering with Brandon Lord, whose ERA has ballooned from 3.26 to 4.21 over his past 5 outings. During this stretch the right-hander has allowed 18 runs (17 earned) in 24.1 innings. Lord has walked multiple batters in 6 of his last 8 appearances. All of this sets of very well for the Braves, who are going for a 4-game sweep. They took the first 3 contests of this series by a combined 22-6 margin, extending their overall winning streak to 4. The Nationals have dropped 6 of their last 8 overall.
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