Nebraska vs Northwestern expert picks, odds and best bets for Saturday: Wildcats roar in Dublin

Northwestern Wildcats quarterback Ryan Hilinski (12) hands the ball to Northwestern Wildcats running back Evan Hull (26) during the first half against the Illinois Fighting Illini at Memorial Stadium.
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Managing Editor of Pickswise. Born and raised in jolly old London, England, with an undying love for the NFL, NBA, soccer and horse racing. A big-time sports bettor who loves futures markets and backing underdogs. Long-suffering New York Jets fan. For Andrew Wilsher media enquiries, please email
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The 2022 college football season kicks off in Dublin, Ireland, as the Nebraska Cornhuskers take on the Northwestern Wildcats at the Aviva Stadium at 12:30 pm ET on Saturday. Let’s take a look at the odds and our expert picks for this Big Ten matchup. Make sure you also check out our College Football picks page, where we provide bets on the side and total for every game involving a Power 5 conference team.

Nebraska vs Northwestern odds

Odds courtesy of DraftKings Sportsbook

Nebraska Cornhuskers vs Northwestern Wildcats money line odds

Nebraska Cornhuskers -425
Northwestern Wildcats +340

Nebraska Cornhuskers vs Northwestern Wildcats spread odds

Nebraska Cornhuskers -12 -110
Northwestern Wildcats +12 -110

Nebraska Cornhuskers vs Northwestern Wildcats over/under game total odds

Over 50.5 -110
Under 50.5 -110

Nebraska vs Northwestern spread prediction: Northwestern +12 (-110)

Nebraska head coach Scott Frost starts the 2022 college football season firmly in the hot seat after a disappointing but unlucky campaign last year, where the Cornhuskers’ 9 losses all came by single digits. The Cornhuskers will be looking for a bounce-back season and will be excited to take on a Northwestern team that they hammered 56-7 last year. However, Wildcats quarterback Ryan Hilinski should be much-improved under center and is capable of keeping his team in the mix, especially in the opening game of the season. With this matchup taking place on a neutral site in a different country, both teams will be affected by the time difference which could also result in a close contest.

Be sure to check out our Nebraska vs Northwestern predictions

Nebraska vs Northwestern over/under prediction: Over 50.5 (-110)

These teams combined to score 63 points in last year’s matchup, with Nebraska contributing 56 themselves, and they should be able to kick off the 2022 college season with a bang. Northwestern’s offense was woeful last year but Hilinski has the potential to improve this year and help his team put up their share of the points. Only 5 starters return to these teams’ defenses, and while they look to gel the early advantage should go to the offenses. The Cornhuskers will have a new QB under center in Casey Thompson, who should be motivated to put on a show. Expect an explosive encounter in Ireland.

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