The NFL season is rolling right along, as Week 10 is already underway after Denver’s win over Las Vegas on Thursday Night Football. Sunday’s Week 10 card should make for must-see TV, starting as early as 9:30am ET when the Atlanta Falcons and Indianapolis Colts kick off from Berlin, and ending with an AFC clash with postseason implications between the Steelers and the Chargers on Sunday Night Football.
Here at Pickswise, we have you covered on EVERY GAME on the Week 10 menu! You can find our NFL picks for EVERY side and total, and tail our expert handicappers – who collectively boast a 145-123-2 record so far this season! But for now, let’s break down our NFL best bets from our top experts.
NFL Best Bet: Atlanta Falcons vs Indianapolis Colts Under 48.5 (-110)
Odds available at bet365 the time of publishing.
Games across the pond tend to be ugly, low-scoring slogs. This one may be no different, so my Falcons vs Colts pick is under 48.5. Going into this season, NFL experts and casual fans alike figured that the Falcons’ offense would be the strength of the team. However, that has not been the case through 8 games. They need running back Bijan Robinson to get back on track. Since running wild against the Bills back in Week 6, he has been held to 40, 25 and 46 rushing yards over the past 3 outings. It’s also worth noting that Michael Penix Jr. and the passing attack now has to go up against the recently acquired Sauce Gardner. His acquisition from the Jets prior to Tuesday’s trade deadline gives Indy’s secondary an immediate boost.
Meanwhile, which version of Jones will show up for the Colts? Through his team’s first 8 contests, he tossed 13 TD passes while being picked off only 3 times. Against the Steelers he committed 5 turnovers (3 INTs and 2 lost fumbles). After getting sacked 5 times, Jones now faces an improved Atlanta pass rush that had 3 different guys record 2 sacks last week (Jalon Walker, Brandon Dorlus and LaCale London). All things considered, this is another international game that has the makings of a defensive struggle.
Read our full Falcons vs Colts prediction
NFL Best Bet: New England Patriots +2.5 over Tampa Bay Buccaneers (-105)
Odds courtesy of Fanatics Sportsbook at the time of publishing.
A pair of division leaders meet for a critical matchup at Raymond James Stadium on Sunday. Not many people should be surprised that Tampa Bay sits atop the NFC South at 6-2 and is tied with 3 other teams for the best record in the conference. However, the Patriots were not expected to lead the AFC East halfway through the season at 7-2, ahead of the 5-time defending division champion Buffalo Bills.
New England lost 2 of its first 3 games, falling at home to Las Vegas and Pittsburgh, but the Pats have ripped off 6 consecutive victories – including 3 wins over NFC South opponents. New England held off Atlanta last Sunday 24-23, as the Falcons missed the game-tying extra point with less than 5 minutes remaining. During this hot streak, the Patriots have covered the pointspread 5 times, including in its lone game as an underdog in a 23-20 upset of the Bills in Week 5.
The Buccaneers bounced back from a 24-9 loss at Detroit in Week 7 to beat the Saints in Week 8 23-3 as 4-point road favorites. It was the best defensive effort of the season for Tampa Bay out of the bye week, who won in spite of scoring 1 offensive touchdown. The Bucs are beat up offensively, as future Hall of Fame WR Mike Evans is sidelined for the rest of the season with a broken collarbone suffered in the loss to the Lions.
Patriots QB Drake Maye has made an incredible ascension in his 2nd season, throwing multiple touchdown passes in 7 of the last 8 games. The former North Carolina standout hasn’t thrown for 300 yards in a game this season, though he has surpassed the 250-yard threshold 6 times. Incredibly, New England is 4-0 on the road in 2025 after going 2-7 away from Gillette Stadium last season. Tampa Bay owns 4 walk-off wins this season and probably isn’t as strong as its 6-2 mark, not to mention, the Bucs are dealing with a bunch of injuries. Let’s back the Patriots here as a road underdog.
We have picks on the side and total in our Pats vs Bucs prediction
NFL Best Bet: Carolina Panthers -5.5 over New Orleans Saints (-108)
Odds courtesy of FanDuel Sportsbook at the time of publishing.
It will be a battle in the NFC South when the New Orleans Saints and Carolina Panthers collide in Week 10 of the NFL season on Sunday afternoon at Carolina. The Panthers (5-4) have been better than expected so far. Unfortunately for the Saints, they have been just as advertised–terrible. They are 1-8 and their lone win has come in a game in which the other team (the Giants) committed a ridiculous 5 turnovers and forced none. In other words, the Saints should be 0-9. Now they have to face an opponent that just beat Green Bay at Lambeau Field. Yeah, I’m not envisioning this game being competitive at all. My Saints vs Panthers pick is on the home side to win and cover.
New Orleans started the season in bad form and has actually gotten worse. First-year head coach Kellen Moore’s crew has not kept a game within 12 points since Week 6and its 2 most recent losses have come by a combined margin of 57-13. Rookie quarterback Tyler Shough got his first NFL start this past weekend Sunday and the Saints’ offense was predictably inept during a 34-10 blowout by the Rams. Shough threw for 176 yards with 1 touchdown and 1 interception. Meanwhile, Carolina has won 4 of its last 5 games and its only home loss this season is to a high-powered Buffalo outfit. Give me the Panthers to win big.
Find our full Saints vs Panthers prediction
NFL Best Bet: Los Angeles Rams -4.5 over San Francisco 49ers (-110)
Odds widely available at the time of publishing.
The last time the Rams and 49ers got together in Los Angeles in Week 5, it turned into one of the wildest games of the season. San Francisco blew an early 14-0 lead, as Los Angeles rallied back to force overtime tied at 23-23. The 49ers kicked the go-ahead field goal on their first drive in OT, followed by stuffing the Rams on 4th and 1 to close out a 26-23 win as 8.5-point underdogs. QB Mac Jones torched the Rams defense for 342 yards and 2 touchdowns to end a 3-game losing streak to Los Angeles dating back to 2023.
The race for first place in the NFC West down the stretch will be a good one, as Seattle and Los Angeles are tied at 6-2 with San Francisco right behind at 6-3. The Rams are riding a 3-game winning streak since that heartbreaking loss to the 49ers, coming off a 34-10 blowout of the hapless Saints last Sunday as a 14.5-point favorite. Los Angeles could have easily won the 2 games it lost, starting in Philadelphia in Week 3 when the Rams squandered a 26-7 lead in a 33-26 defeat.
San Francisco has alternated wins and losses in each of the 7 games, as the 49ers cruised past the Giants last Sunday, 2.5-point road favorites. Kyle Shanahan’s team is 1-4 against the spread this season following a win, while giving up at least 26 points in the last 3 games off a victory. The 49ers have intercepted 1 pass the whole season, while Rams QB Matthew Stafford has thrown only 2 interceptions. The Rams have won and covered in all 3 victories away from SoFi Stadium, while winning each of the last 2 visits to Santa Clara. After coming out flat early against the 49ers in the first matchup as a heavy favorite, this is a good buy-low spot on the Rams as a short road favorite.
Don’t forget to check out our Rams vs 49ers prediction for a pick on both side and total
NFL Best Bet: Pittsburgh Steelers +3 over Los Angeles Chargers (-115)
Odds available at DraftKings Sportsbook at the time of publishing.
The Chargers pulled out their 2nd straight win and moved to 6-3 on the season, but it didn’t come easy. Playing with nothing to lose, the Titans were at their best on Sunday, finally getting through a full game without a turnover. Their offense still wasn’t enough to do anything significant against Jim Harbaugh’s defense, though, a group that held Tennessee to just 20 first downs and 206 yards. The visiting Chargers controlled most of the matchup, behind another Herculean effort by Justin Herbert (250 passing yards, 57 rushing yards, 3 total touchdowns). Their rushing attack, which was led by 2nd-year back Kimani Vidal, was their biggest letdown of the week, netting only 74 yards on 21 carries between Vidal and Jaret Patterson.
Despite a win, the biggest news from Chargers’ camp was Joe Alt’s season ending ankle injury. The left tackle, who was rated higher than any other player at his position this season, was a massive part of the Bolts’ offense. Without him, the Chargers obviously regressed in weeks prior, starting with a loss at the Giants, a loss versus Washington, a closely-fought game against the Dolphins and another loss versus the Colts. In every contest, their offense was more challenged without the 6’8” Alt. Upon his return, the Chargers’ offense instantly looked explosive, affording Herbert more time on every play, until he went down on Sunday. Making matters worse, right tackle Bobby Hart, who’s played well as the Chargers’ front continued to incur injuries, went down with an ankle and groin injury this past Sunday. The Chargers’ injury issues should not be understated, nor would we expect the same production moving forward, although they did trade for Trevor Penning, a veteran left tackle from New Orleans. It remains to be seen how formidable he’ll be in Alt’s absence.
The Steelers are experiencing no such issues. In their best defensive performance of the season, Pittsburgh caused havoc in Week 9 in all the ways we’ve got accustomed to seeing from the star-studded group. As a unit, they had 13 passes deflected, 5 sacks, 5 QB hits, 6 tackles for a loss, and forced 6 turnovers. It was a sterling reminder of what the Steelers’ defense could be every week if they played up to their potential. Their offense, which continues to defy expectations (25.3 points per game, 12th) despite a shallow roster surrounding Aaron Rodgers, did enough in Week 9, although it was their defense that manufactured the win.
Rodgers and the Steelers’ offense has its struggles, a group that’s 28th in yards per carry (3.8) and 19th in yards per pass (7.0), but we think they can win plenty on defense. Mike Tomlin is an outrageous 67-40-4 (62%) ATS as an underdog, and we like him to get another this Sunday night.
Here are our Steelers vs Chargers predictions for SNF
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