NFL Best Bets for Week 7: Expert Picks for Rams vs Jaguars, Commanders vs Cowboys, Falcons vs 49ers, and More

We are rapidly approaching the halfway point of the NFL season, as Week 7 is now underway after a thrilling divisional matchup on Thursday night in which Joe Flacco and the Bengals beat the Steelers. As always, Sunday’s NFL slate really packs a punch. We will have another game in the London Series (this time Rams vs. Jaguars), an intriguing divisional matchups between the Cowboys and Commanders, and multiple non-divisional matchups that should be fascinating to watch like Eagles vs. Vikings and Falcons vs. 49ers.

Here at Pickswise, we have you covered on EVERY GAME on the Week 7 card! You can find out our NFL picks on the side and total, and tail our expert handicappers – who collectively boast a 106-81-1 record so far this season for more than +40 units after a 2-0 start to the week on Thursday Night Football! But for now, let’s break down our NFL best bets from our top experts.

NFL best bet: Jacksonville Jaguars +3 over Los Angeles Rams (-105)

Odds available at DraftKings Sportsbook at time of publishing.

The next London game on the NFL slate is this Week 7 matchup between the Los Angeles Rams and Jacksonville Jaguars in a battle of 4-2 teams. Jacksonville was riding high off its signature primetime win over the Chiefs, and then came crashing back down to earth last week in a loss to the Seahawks. While I don’t think the Jags were ever as good as their 4-1 record suggested, I also don’t think the Rams deserve to be 3-point favorites here.

The Jaguars’ loss to Seattle has more to do with the Seahawks just being a legitimately-good team than anything else, and I’m not overreacting after 1 week – just like I wasn’t overreacting after their win over Kansas City. Liam Coen has something cooking, and the ground game is back with Travis Etienne averaging 5.3 yards per carry. I haven’t been all too impressed by the Rams even though Matthew Stafford has played at a high level, and I’m not giving them much credit at all for beating a Cooper Rush-led Ravens team last week.

Just the week before, the Rams lost to Mac Jones at home. Los Angeles’ 4 wins this season have come against a Texans team that started the year terribly, an awful Titans team, the Colts in a fluky game where Indy blew the game by dropping the ball at the goal line, and then Rush last week. The Jaguars have played in London a ton in recent years and they played there twice last year, so they won’t have to make nearly as much of an adjustment as the Rams and should acclimate better. Give me the underdog in this spot.

Read our full Jaguars vs Rams prediction for this London Series matchup

NFL best bet: Carolina Panthers vs. New York Jets Under 42.5 (-118)

Odds available at FanDuel Sportsbook at time of publishing.

Just how bad is the Jets’ passing attack? Their 144.2 yards per game are 6.3 fewer than the pathetic Titans and at least 24.3 fewer than every other team in the NFL. What’s amazing is that New York is this bad even though Justin Fields has not thrown a single interception yet this season. Just think how hopeless the offense will be once Fields starts forcing things and getting picked off! The Jets’ only real hope is to keep the football on the ground, but the Panthers rank #9 league-wide against the run, surrendering just 94.5 yards per contest on 4.1 yards per carry. That is part of the reason why my Jets vs Panthers prediction is under 42.5.

Adding insult to injury, or vice versa, New York wide receiver Garrett Wilson is doubtful for Sunday due to a knee problem. WR2 Josh Reynolds (hip) did not practice on Wednesday and is questionable. There is no reason to think that things will suddenly improve for Fields when he could be without 2 of his primary pass-catching targets. Fortunately for the Jets, they can at least play some semblance of defense thanks to CB Sauce Gardner and DT Quinnen Williams. Meanwhile, the Panthers have 3 offensive starters listed as questionable: RB Chuba Hubbard, TE Ja’Tavion Sanders and OT Taylor Moton. Since Young is inconsistent and Hubbard (who might not even play) has done nothing on the ground so far in 2025, Carolina does not inspire much confidence on offense. I’m backing the under with confidence.

Don’t forget to check out our full Panthers vs Jets prediction

NFL best bet: New England Patriots -7 over Tennessee Titans (-109)

Odds available at Caesars Sportsbook at time of publishing.

The New England Patriots surprisingly find themselves atop the AFC East heading into Week 7 of the NFL season. They are 4-2 and own the head-to-head tiebreaker over the Bills, having taken down Josh Allen and company in Buffalo earlier this month. New England now faces arguably the worst team in football, the Tennessee Titans, on Sunday afternoon. This is a tale of 2 franchises going in opposite directions — and with the spread set at no more than a touchdown, my Patriots vs Titans pick is for the visitors to win and cover. Tennessee just fired head coach Bill Callahan – and for good reason. The Titans 1-5 and their only win is a miracle (“fluke” would probably be an even more accurate description) fourth-quarter comeback from 15 points down against the Cardinals, made possible by Arizona RB Emari Demarcado dropping the ball before going into the endzone followed by one of the luckiest touchdowns in football history after Arizona fumbled an interception. 

Teams can sometimes galvanize around an interim head coach, but that’s usually when they have a chance to really turn around the season. That obviously isn’t the case with Tennessee. The Titans know as well as everyone else that this is a rebuilding process that will require multiple years. Now they are being asked to compete with a team is on a 3-game winning streak and has lost just once since Week 1 in a 1-possession game against the 4-1 Steelers? Drake Maye looks like the real deal at quarterback and New England is 3-0 on the road. It’s not like the Titans have any kind of significant home-field advantage, either, so the Patriots should be even bigger favorites and can be expected to win by more than a touchdown. 

Our expert has a pick on the side and total in our Patriots vs Titans prediction

NFL best bet: Washington Commanders -1 over Dallas Cowboys (-105)

Odds available at bet365 at time of publishing.

These two teams sit right behind the Eagles for first place in the NFC East as Washington (3-3) heads to Dallas (2-3-1) on late Sunday afternoon. Both squads are coming off losses last week in heartbreaking fashion. The Commanders rallied from a 13-0 deficit to lead the Bears on Monday night, 24-16 in the fourth quarter. Chicago scored the final 10 points of the game, capped off by a game-winning field goal in the final seconds for a 25-24 triumph. Meanwhile, Dallas went back and forth with Carolina on the road before allowing the go-ahead field goal as time expired in a 30-27 defeat to the Panthers. It marked the fourth time in the last five games that the Cowboys yielded at least 30 points, while being the only team in the league to give up an average of over 400 yards a game.

Commanders’ QB Jayden Daniels has thrown four touchdown passes in the past two games after returning from a knee injury. In each of his last three starts, Washington has trailed by double-digits before scoring their first points. Dallas has played probably the two of the most exciting games of the season at AT&T Stadium. The Cowboys outlasted the Giants in overtime in Week 2, 40-37 and rallied to tie the Packers, 40-40 in Week 4. The offense has been great, but they will get back one of its top weapons in WR Ceedee Lamb, who is expected to return following a four-game absence with an ankle injury.

Last season, the road team won each matchup as Dallas held off Washington, 34-26 in D.C., while the Commanders rallied late against the Cowboys in Arlington, 23-19. In both games, the Cowboys played without QB Dak Prescott, who was sidelined for the season halfway through. Prescott threw four TD passes in each of the two wins over Washington during the 2023 season, but the Commanders finished 4-13 before drafting Daniels the following spring. Dallas is 6-2 against the spread in its last eight opportunities as an underdog since last November. However, seven of those covers came as a ‘dog of at least four points. In this spot, let’s back Washington as a short favorite to grab the road victory.

Find our Commanders vs Cowboys prediction for this NFC East showdown 

NFL best bet: San Francisco 49ers -2 over Atlanta Falcons (-110)

Odds available at BetMGM at the time of publishing.

This is the definition of a regression game on both sides. We’ll start with the 49ers. San Francisco will be coming off a tough loss at Tampa in Week 6 but they have plenty to hang their hats on. Veteran all-pro linebacker Fred Warner sustained an injury early in the game and Mac Jones threw 2 interceptions, but the visitors were still in a one score game entering the fourth quarter. The Bucs did a nice job closing it out late, but it was largely an even matchup. For example, San Francisco gained 363 yards while Tampa gained 352. Despite their many injuries on both sides of the ball, the 49ers went toe-to-toe in enemy territory with one of the best teams in the NFL. I left feeling better about their potential this season, regardless of the dwindling health of their roster.

This Sunday sets up beautifully for a redemption spot. Early in the week, reports out of the 49ers camp suggest that George Kittle, Brock Purdy and Ricky Pearsall are all trending toward playing on Sunday night. Kittle has the most challenging journey to return, since his 12 day practice window just opened following 4 weeks on the injured reserve. Heading back home following a disappointing loss, San Francisco will take any healthy returning player that they can get.

The Falcons did nothing but impress in their Week 6 victory over the Bills on Monday Night Football, but there is also some reason to believe it was fluky. Firstly, the game started on a Bijan Robinson fumble and Bills’ recovery, but Buffalo was offside and it negated the turnover. The Bills also have serious issues with their run-defense, so predictably they were overwhelmed by Robinson and Tyler Allgeier — arguably the best rushing-duo in the NFL. The 49ers don’t have the same issues, ranking 12th in yards per carry allowed. Atlanta mostly won via big plays in their ground attack, with Robinson and Allgeier galloping down the sidelines on seemingly every possession. We doubt their offense can be that simple and still experience the same success against an above-average defensive coordinator in Robert Saleh. This fits a pattern we love; an overconfident team on the road following a strange win against a home team getting healthier and historically more buttoned up than the opponent. The value is clear.

Here is our Falcons vs 49ers prediction for SNF