NFL Computer Picks Week 1 Against The Spread and Score Projections

Buffalo Bills quarterback Josh Allen (17) tried a 4 down and 21 pass but it was inclomplete to ice the game for the Jets at MetLife Stadium.
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Ben Harris

NFL

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Passionate Sports enthusiast and history graduate. Writing sports betting content for over 6 years, including handicapping college football, horse racing, and soccer at the UK's top daily betting paper the Racing Post, as well as NFL, Boxing, UFC, and Winter Sports here at Pickswise. Partial to an underdog, player prop, and a longshot parlay!
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Our NFL computer picks are unbiased, entirely data-driven NFL predictions using machine-learning techniques as inputs to a Monte Carlo approach. That means we simulate an NFL game more than 10,000 times, considering the full range of outcomes and probabilities.

Check out all of our Week 1 NFL Computer Picks Against The Spread, the Over/Under Points Totals, and our score projections for every game this weekend, below.

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Carolina Panthers vs Atlanta Falcons Computer Picks & Score Predictions

Score Projection: Panthers 22 Falcons 21

ATS Prediction: Panthers +3.5

O/U Prediction: Over 39.5 points

Tampa Bay Buccaneers vs Minnesota Vikings Computer Picks & Score Predictions

Score Projection: Buccaneers 21 Vikings 24

ATS Prediction: Buccaneers +6

O/U Prediction: Under 45.5 points

Cincinnati Bengals vs Cleveland Browns Computer Picks & Score Predictions

Score Projection: Bengals 26 Browns 19

ATS Prediction: Bengals -2.5

O/U Prediction: Under 48.5 points

Jacksonville Jaguars vs Indianapolis Colts Computer Picks & Score Predictions

Score Projection: Jaguars 24 Colts 20

ATS Prediction: Colts +5

O/U Prediction: Under 45.5 points

San Francisco 49ers vs Pittsburgh Steelers Computer Picks & Score Predictions

Score Projection: 49ers 26 Steelers 20

ATS Prediction: 49ers -2.5

O/U Prediction: Over 41 points

Tennessee Titans vs New Orleans Saints Computer Picks & Score Predictions

Score Projection: Titans 20 Saints 21

ATS Prediction: Titans +3

O/U Prediction: Over 41 points

Arizona Cardinals vs Washington Commanders Computer Picks & Score Predictions

Score Projection: Cardinals 21 Commanders 22

ATS Prediction: Cardinals +7

O/U Prediction: Over 38 points

Houston Texans vs Baltimore Ravens Computer Picks & Score Predictions

Score Projection: Texans 18 Ravens 26

ATS Prediction: Texans +10

O/U Prediction: Over 43.5 points

Philadelphia Eagles vs New England Patriots Computer Picks & Score Predictions

Score Projection: Eagles 25 Patriots 20

ATS Prediction: Eagles -4

O/U Prediction: Over 45 points

Download the Pickswise app to get all of our NFL Computer Picks, model projections, and best bets for every game, every week.

Las Vegas Raiders vs Denver Broncos Computer Picks & Score Predictions

Score Projection: Raiders 25 Broncos 22

ATS Prediction: Raiders +3.5

O/U Prediction: Over 44 points

Miami Dolphins vs Los Angeles Chargers Computer Picks & Score Predictions

Score Projection: Dolphins 22 Chargers 23

ATS Prediction: Dolphins +3

O/U Prediction: Under 51 points

Los Angeles Rams vs Seattle Seahawks Computer Picks & Score Predictions

Score Projection: Rams 23 Seahawks 23

ATS Prediction: Rams +5

O/U Prediction: Under 46.5 points

Green Bay Packers vs Chicago Bears Computer Picks & Score Predictions

Score Projection: Packers 26 Bears 17

ATS Prediction: Packers +1

O/U Prediction: Over 42 points

Dallas Cowboys vs New York Giants Computer Picks & Score Predictions

Score Projection: Cowboys 26 Giants 20

ATS Prediction: Cowboys -3.5

O/U Prediction: Over 46 points

Buffalo Bills vs New York Jets Computer Picks & Score Predictions

Score Projection: Bills 29 Jets 16

ATS Prediction: Bills -2.5

O/U Prediction: Under 45.5 points

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