NFL DFS Monday Night Football showdown lineup advice: Rams vs 49ers

Los Angeles Rams running back Darrell Henderson (27) carries the ball in the first half against the Arizona Cardinals at SoFi Stadium.
Photo of Howard Bender

Howard Bender

NFL· 2 weeks ago

Show Bio

I have been working in the fantasy sports industry for more than 20 years. I am the head of fantasy sports content for Fantasy Alarm and DFS Alarm as well as a bi-weekly columnist for the New York Post. Welcome to the #Family.

Welcome to daily fantasy football, Pickswise users. For those who haven’t yet dipped their toes into the DFS pool, allow me to introduce myself. My name is Howard Bender and I have been working in the fantasy sports industry for more than 20 years. I am the head of fantasy sports content for Fantasy Alarm and DFS Alarm as well as a bi-weekly columnist for the New York Post. We’ve enjoyed tremendous success over the years, but this NFL season has been one of our best as our Playbook and Showdown write-ups have already brought in a million-dollar winner on FanDuel as well as several others who have enjoyed six-figure wins. We promote the process and teach you to be a better DFS player and that has certainly been the case this year. Welcome to the #FAmily….

As we head into Monday Night Football for NFL Week 10 between the Los Angeles Rams and the San Francisco 49ers, the hope is that we get a hard-fought, competitive game between two division rivals. Anything but what we saw Sunday when eight of the 12 games were decided by at least a two-score differential with four or five blowouts. If we base it on what has happened thus far, we could be in trouble as the 49ers are 0-3 in the division and 0-4 at home this season. However, the 49ers have also won the last four meetings between these two teams with an average score differential of less than a touchdown. The over/under of 50 indicates an action-filled, high-scoring affair, so let’s take a look at how we should set up our DFS Showdown lineups.

Captain/MVP

Matthew Stafford, QB LAR

His overall numbers are up across the board and now he takes on a pass defense that may not give up a ton of passing yards (just 206.5 per game), but routinely struggles in coverage, as evidenced by the ranking of 25th in DVOA against the pass. Over his last three games, Stafford has averaged 311 passing yards and has a 7:2 TD:INT. With opposing quarterbacks posting a 102.0 passer rating against the 49ers, Stafford’s numbers should fall in line here.

Cooper Kupp, WR LAR

He’s Stafford’s best friend in the whole wide world and he’s got the targets, target share, receptions, receiving yards and touchdowns to prove it. With Robert Woods out and Odell Beckham still learning the Rams system, expect a heavy lean on Kupp tonight.

George Kittle, TE SF

The Rams may rank eighth in DVOA against the tight end, but they’re allowing the seventh-most fantasy points and an average of 64 receiving yards per game to them. Kittle returned from injured reserve last week and immediately led the team with eight targets, six catches, 101 receiving yards and a touchdown. He’ll remain a focal point of this offense tonight and every game moving forward.

Other Picks

Deebo Samuel, WR SF

It will be interesting to see if Jalen Ramsey stays in the slot all game or if he shadows Samuel at any point. Samuel has mostly played on the outside with just 28-percent of his snaps coming out of the slot, so if Ramsey, who has played 44-percent of his snaps as the slot-corner, doesn’t shadow, he’ll have a much easier time gaining separation. If we haven’t heard anything by game-time, get Samuel into those lineups.

Darrell Henderson, RB LAR

The 49ers may rank sixth in DVOA against the run, but they are allowing 131.6 rushing yards per game and have given up 12 touchdowns on the ground. The Rams will likely give a lot of early work to Henderson and allow play-action to develop and open things up for the pass. His fantasy numbers have run hot and cold recently but he still has five touchdowns in his last five games

Elijah Mitchell, RB SF

With no injury designation this week and JaMycal Hasty out, you can expect Mitchell to lead this backfield in carries once again. He had nearly 80 all-purpose yards in a tough loss to Arizona last week, but posted a 100-yard effort with a touchdown in each of the two prior games. The Rams may be allowing fewer than 100 rushing yards per game but they’ve coughed up 10 touchdowns on the ground this season.

Van Jefferson, WR LAR

Woods is out for the season and OBJ is still learning the ropes, so perhaps the value of Jefferson stays intact this week. He’s seen 20 targets over the last three games, but has just a 50-percent catch rate and only one touchdown to show for it. However, if there was ever a golden opportunity for him to shine, it would be here. A big game tonight could entrench him as the team’s No. 2 while Beckham stays on as the deep threat.

Brandon Aiyuk, WR SF

He’d be more well-liked if Ramsey is shadowing Samuel, but even if he isn’t, Aiyuk has garnered more attention recently with 15 targets which he turned into 10 catches for 134 yards and one touchdown over his last two games. If he can continue to see this kind of volume, he’ll be worth an add to your lineups.

Odell Beckham, WR LAR

You know the Rams are going to find ways to take their shiny, new toy out for a spin. He’ll slot in as the deep threat for Stafford and should see a handful of targets come his way. If he can convert one for a really big play, he’ll earn the value you need.

Dart Throw

Jeff Wilson, RB SF

Though he was activated from injured reserve for last week’s game, Wilson didn’t play a single snap. That should change this week with Hasty out and he should fill the role as the third-down/goal-line back. A handful of catches and one touchdown poached from Mitchell could be the difference you need to cash in tonight’s contests.

For a more in-depth breakdown and showdown analysis, be sure to check out DFSAlarm.com for all of your daily fantasy sports needs.

See All
FanDuel Sportsbook

$50

Get $50 Free - No Deposit Required!

Register for a FanDuel Sportsbook account

Receive $50 in site credits to use on Sportsbook

No Deposit Required!

Winnings paid as CASH. 21+ and new players only. Full terms available at FanDuel Sportsbook.

DraftKings

$100

Win $100 if any team scores a point in any NFL, NBA, CFB, or CBB game!

Register for a new DraftKings Sportsbook account

Bet $1+ any NFL, NBA, CFB, or CBB game Money Line

If your team wins, you will be issued a $100 free bet bonus!

Must be 21+ located in AZ, CO, CT, IA, IL, IN, MI, NJ, PA, TN, VA, WY or WV to play. Offer valid only for new customers. Full terms available at DraftKings Sportsbook.

BetMGM

$200

Bet $10, Get $200 If Your Team Scores A Touchdown!

Register for a new BetMGM account & deposit $20+

Bet $10 on your team to win Money Line

Win $200 in free bets if your team scores a touchdown

21+. Terms & conditions apply.

PointsBet

$200

Bet $20, Get $200 If Your Team Scores A Touchdown!

Register for a new PointsBet account & deposit $20+

Bet $20 on your team to win Money Line (NFL or NCAAF)

Win $200 in free bets if your team scores a touchdown

Caesars Sportsbook

$1,001

Get a $1,001 Free Bet!

Register for a new Caesars Sportsbook account & make a deposit

Place your first bet up to $1,001

Win or lose, you'll receive a free bet matching your initial stake - up to $1,001!

21+. Terms & conditions apply.

BetRivers

$250

Get a $250 Deposit Bonus!

Sign up for a new BetRivers account using promo code PICKSWISE

Make a deposit & get it doubled up to $250 total

To get a $100 bonus, deposit $100

Must be 21+. Play in IA Only. Gambling Problem? Call 1-800-BETS OFF

BetMGM

$1,000

Get a $1,000 Risk Free Bet!

Register for a new BetMGM & deposit

Place your first bet up to $1,000 risk-free!

Get refunded up if you lose up to $1,000

21+. Terms & conditions apply.

FanDuel Sportsbook

$1,000

Get a $1,000 Risk Free Bet!

Register for a new FanDuel Sportsbook account & deposit

Place your first bet up to $1,000 risk-free!

Get refunded up if you lose up to $1,000

21+. Terms & conditions apply.

DraftKings

$1,000

Get a $1,000 Deposit Bonus!

Register for a new DraftKings Sportsbook account & deposit

DraftKings will match 20% of your deposit up to $1,000 total

To get a $100 bonus, deposit $500

21+. Terms & conditions apply.

Unibet

$500

Get a $500 Risk-Free Bet!

Register for a new Unibet account & make a deposit

Place your first bet up to $500 risk-free!

Get refunded up if you lose up to $500

New players only. Terms & conditions apply. 21+. VA only.

Monkey Knife Fight

$100

Claim 100% Instant Deposit Match up to $100!

Register for a Monkey Knife Fight account & deposit using promo code PICKSWISE100

Monkey Knife Fight will match your first deposit up to $100

Deposit $100 and you'll get $100 bonus + a free $5 game

18+. Terms and conditions apply. You must live in one of the states where real money DFS is legal.

TVG

$300

Get a $300 Risk-Free Bet with TVG Racebook!

Register for a new TVG account and make a deposit

Place your first single horse win-type bet up to $300

If your horse doesn't win you'll get a refund up to $300

21+. T&C's apply. Please gamble responsibly.

BetAmerica Racing

$200

$200 Sign Up Bonus!

Fast, reliable and fast payouts - you'll have your money in 72 hours, if not sooner!

Proud history of providing safe, secure, and fun betting to American patrons

BetAmerica is owned by the iconic Churchill Downs Incorporated, home of 150 years of wagering history and the world-famous Kentucky Derby

Players who sign up using ‘BET200’ code will get a $200 sign up bonus. Offer valid for 7 days after registering on BetAmerica Racing product only. 21+. T&C's apply. Please gamble responsibly.

TwinSpires

$400

Get a $400 Risk-Free Bet on the Breeders' Cup!

Register for a new Twinspires account using offer code PICKS400

Place a bet on the Breeders' Cup

Receive a refund if your first bet loses up to $400

21+. T&C's apply. Please gamble responsibly.