NFL Week 10 parlay at mega +1199 odds on Sunday 11/12: Jaguars claw out victory over 49ers

Travis Etienne and Trevor Lawrence of the Jacksonville Jaguars
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Andrew Wilsher


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Managing Editor of Pickswise. Born and raised in jolly old London, England, with an undying love for the NFL, NBA, soccer and horse racing. A big-time sports bettor who loves futures markets and backing underdogs. Long-suffering New York Jets fan. For Andrew Wilsher media enquiries, please email

Week 10 of the NFL season got started with a snoozefest between the Bears and Panthers, but Sunday’s slate promises to be a much more exciting day of action. We have the Colts battling the Patriots in Germany at 9:30 am ET to kick us off, before a strong 10 games to carry us through to Sunday Night Football. I’ve already cashed 2 NFL mega parlays this season at +1457 and +1381 odds, and now I’m looking to secure another one! Let’s dive into my NFL mega parlay for Week 10, but make sure you also ready our NFL picks for every game.

Jaguars ML (+142)

Browns ML (+235)

Commanders +7.5 (-166) 

NFL parlay odds: +1199

For this parlay, I’m taking 2 underdogs on the money line and another dog on an alternate spread. Let’s break each of them down.

Jacksonville Jaguars ML over San Francisco 49ers (+132)

To start off this NFL mega parlay, we’re taking the Jaguars to pull of the victory against the 49ers. It’s not everyday you get a 6-2 team as a home underdog against a 5-3 team, but that’s what we have here. Public perception remains high on San Francisco following their 3-game skid, but I’m not so sure. There’s no doubting their relentless defense and the ability of star running back Christian McCaffrey, but I have a feeling that the true Brock Purdy is beginning to show himself and I’m not so sure he has what it takes to take the 49ers all the way. Now they’re coming up against a Jacksonville team that is fresh off their bye and has won 5 in a row. Trevor Lawrence is looking red-hot with Calvin Ridley and Christian Kirk at his disposal, while running back Travis Etienne has been a touchdown machine. Give me the Jags to pile more pressure on the 49ers.

Read our full San Francisco 49ers vs Jacksonville Jaguars predictions

Cleveland Browns ML over Baltimore Ravens (+235)

This one feels like a bit of a moonshot, but hear me out. I know that the Ravens have won their last 2 home games by a combined score of 75-9 against the Lions and Seahawks, but I’m still not totally sold on them, and I can see the Browns pulling an upset. This Cleveland defense has looked phenomenal so far this season, and they could easily be sat atop the AFC North themselves right now were it not for Deshaun Watson’s injury issues. However, Watson appears to be back to full health now and should be able to navigate this offense to a win. This pick is all about whether the Browns’ defense can step up and shut down the Ravens’ offense while turning this into a slugfest. It awaits to be seen, but at +235 odds I think there’s value in backing Cleveland and finding out.

Read our full Cleveland Browns vs Baltimore Ravens predictions

Washington Commanders +7.5 alternate spread over Seattle Seahawks (-166)

To round off this mega parlay, I’m taking the Commanders to stay within a touchdown against the Seahawks. Washington just traded away two of their star defensive linemen, but they continue to be a battle-hardened team and there’s no way Ron Rivera is ready to call it quits on the season. Despite sitting at 4-5, Washington has covered this spread 7 times in 9 games, and twice this season has taken Philadelphia to the limit. The Seahawks have continued to roll through some excellent coaching from Pete Carroll, but I feel like they are not as good as their record suggests and could be in for a tough matchup against the Commanders. Ultimately I can see Seattle getting the win, but I wouldn’t be surprised if it was in a back-and-forth affair. Give me Washington to keep this one close.

Read our full Washington Commanders vs Seattle Seahawks predictions


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