NFL Week 4 Parlay: Expert 5-leg NFL Parlay Picks for Sunday, September 28

Week 3 of the NFL season is in the books and what a week it was. There was plenty of drama across the slate, including an instant classic between the Rams and Eagles that ended with a play that was very significant to some. While I was unable to cash in on my Week 3 mega parlay, I did cash back in Week 1 at +2512 odds! Can we make it 2 out of 4 this week? It’s time to find out. With the Week 3 Sunday slate on the horizon, let’s get right into my NFL Week 4 mega parlay that pays out at over 22/1 odds at FanDuel Sportsbook.

Rams -3.5 (-105)

Lions -9.5 (-120)

Patriots -5.5 (-110)

Jaguars +3.5 (-120)

Packers -6.5 (-115)

NFL Week 4 parlay odds: +2242

Los Angeles Rams -3.5 over Indianapolis Colts (-105)

Following a rocky tenure with the Giants, Daniel Jones has led the Colts to a 3-0 record and first place in the AFC South. However, I think the cinderella run for Indianapolis ends this week with a trip to Los Angeles for a date with a Rams team that should’ve really knocked off the Eagles last week. Sean McVay’s team ended up dominating that contest for the majority of it, only to surrender a 19-point second half lead and lose on back-to-back blocked field goals within the final 5 minutes. Indianapolis looks great, but this is still a Colts team that has faced 3 opponents that rank in the bottom half of the NFL in yards per game. Now that they’ll be taking on Matthew Stafford and a Rams squad that sits 5th in the league in that metric, things should go differently on Sunday.

Grab our expert’s anytime TD scorer bets for NFL Week 4

Detroit Lions -9.5 over Cleveland Browns (-120)

Ordinarily, I would hate to lay points with a heavy favorite after they’ve come off a huge win, but I’ll make an exception for the Lions in this one. After all, the Browns are also coming off a massive upset over the Packers in which Cleveland was pretty fortunate to rally from a 10-0 deficit in the 4th quarter. The Cleveland offense is certainly not doing this team any favors (30th in EPA per play, 31st in success rate), so I can’t really expect the Browns to greatly improve on the road this week. On the other side, the re-addition of Aidan Hutchinson back into the lineup has certainly been a shot in the arm for this Lions defense, and this is a spot where I’ll trust Jared Goff and the Detroit offense to put up another solid performance at home.

New England Patriots -5.5 over Carolina Panthers (-110)

Both of these teams are coming off games that have a very different feeling when looking at the box score compared to the final score. The Panthers benefitted from a trio of Falcons turnovers (including a pick-6) to race out to a big lead en route to a 30-0 shutout victory, despite the fact that Carolina wasn’t productive on offense. As for New England, the Patriots turned the ball over 5 times, including 4 fumbles, to completely throw the game away against the Steelers last week. With that in mind, it would be reasonable to assume that New England doesn’t fumble the ball 4 more times this week, especially against a Carolina defense that is nothing to write home about. Drake Maye and company are still a top 12 unit in success rate and EPA per play in non-garbage time action, so let’s roll with the home team to put up points and win comfortably.

Read our full Panthers vs Patriots predictions

Jacksonville Jaguars +3.5 vs San Francisco 49ers (-120)

Despite the fact that San Francisco is undefeated, the injuries are starting to mount for the 49ers. Things could reach untenable levels for Kyle Shanahan’s offense this week, and it feels like only a matter of time before the first loss arrives. After all, this is a team that won by one score over Seattle, New Orleans and Arizona. Those aren’t exactly world beaters, so it’s certainly within the realm of possibility that Jacksonville can stay within a field goal here. Jacksonville currently holds a point differential of +29 and their only loss has come by 4 points to the Bengals, a game they led for most of the way. With that in mind, let’s back Trevor Lawrence and company to keep things close, and potentially even win the game outright.

Don’t miss our full Jaguars vs 49ers predictions

Green Bay Packers -6.5 over Dallas Cowboys (-115)

One of the biggest games on Sunday’s card comes in Dallas, where the Cowboys will host the Packers in a game that features Packers linebacker Micah Parsons playing against his former team. However, this is a game where Green Bay’s offense should be the deciding factor against a Dallas defense that has left much to be desired to this point. The Cowboys just allowed nearly 400 yards against the Bears sputtering offense a week ago, and this is a clear step-up in class in that regard. Jordan Love is also coming off his worst game of the season by far, and he should be in a good position to bounce back against a much weaker defense. On the other side of the ball, the Cowboys offense doesn’t give me much confidence without CeeDee Lamb, so let’s lay the points with Green Bay.

Don’t miss our expert’s best bets for NFL Week 4