NFL Week 5 Parlay: Expert 5-leg NFL Parlay Picks for Sunday, October 5

Week 5 of the NFL season is in the books and what a week it was. There was plenty of drama across the slate, including an instant classic between the Rams and Eagles that ended with a play that was very significant to some. While I was unable to cash in on my Week 4 mega parlay, I did cash back in Week 1 at +2512 odds! Can we make it 2 out of 5 this week? It’s time to find out. With the Week 5 Sunday slate on the horizon, let’s get right into my NFL Week 5 mega parlay that pays out at over 22/1 odds at FanDuel Sportsbook.

Vikings 1st half -1.5 (-115)

Seahawks -3.5 (-110)

Chargers -2.5 (-122)

Cowboys -1.5 (-115)

Patriots +8.5 (-110)

NFL Week 4 parlay odds: +2198

Minnesota Vikings 1st half -1.5 over Cleveland Browns (-115)

From a situational perspective, this is a spot where I love backing Minnesota early on in this game. After all, the Vikings will have the benefit of staying overseas after just competing in Europe, while the Browns are coming off a non-competitive loss against the Lions and will have to head back to the states for a game against the Steelers next week. All of this sets up for a pretty sluggish Cleveland team that should be expected to struggle against a Vikings defense that is likely to feast against a depleted Browns offensive line and wide receiver corps. Brian Flores’ defense should have new Browns rookie starter Dillon Gabriel in a world of hurt in his first ever NFL start, and since I have concerns about Minnesota’s offense, let’s avoid the full game and stick with a first half wager in this one.

Grab our expert’s best bets for NFL Week 5

Seattle Seahawks -3.5 over Tampa Bay Buccaneers (-110)

This is one of the better games of the weekend, and I’m rolling with the Seahawks to make a statement at home on Sunday. Seattle has overachieved relative to expectations to this point, and a lot of that is due to Mike Macdonald’s defense (7th in success rate allowed, 8th in EPA per play). The Seahawks run defense in particular has been especially effective, but it’s the Seattle offense that has come alive in recent weeks. Sam Darnold has been torching opposing secondaries over the last few games and given the injuries that Tampa Bay has in its defensive backfield, that could certainly be the case once again in this one. On the other side, Baker Mayfield is due for a ton of turnover regression and this is not the environment that you want to play in when your offensive line is struggling either.

Los Angeles Chargers -2.5 over Washington Commanders (-122)

This Week 5 matchup between the Commanders and Chargers will mark the return of Jayden Daniels, as the Washington quarterback will start under center after missing the last few weeks. Daniels is dynamic, but he’ll be without the services of Terry McLaurin and potentially Deebo Samuel as well. The Chargers defense is one that keeps everything in front of them and limits the explosive play, so it should be a challenge for the Commanders to generate much offensively through the air. As for Los Angeles, the Chargers offensive line woes do worry me, but I’ll trust Justin Herbert and this passing attack to bounce back following an abysmal showing in New York. Look for the hosts to win and cover the short number.

Read our full Commanders vs Chargers predictions

Dallas Cowboys -1.5 over New York Jets (-115)

The Cowboys are certainly one of the more entertaining units in the NFL, but while I tend to stay away from wagering on this version of the Dallas defense, I actually like the spot that this team find itself in on Sunday. The Jets are coming off a game on Monday Night Football that certainly took a lot out of them, and now they’ll have to take on a Cowboys offense that is one of the best in the game on a short week. While the Cowboys are certainly lacking on the defensive side of things, this is a Jets offense that has struggled through the air this season. If Dallas can load the box and focus on stopping the New York ground attack, this should put the Cowboys in a good position to win.

Don’t miss our full Cowboys vs Jets predictions

New England Patriots +8.5 vs Buffalo Bills (-110)

To close out our mega parlay, we’ll back the Patriots to keep things close against the Bills. While Buffalo has traditionally dominated the AFC East in the Josh Allen era, the Bills have struggled a bit with the Patriots in recent seasons. Enter Drake Maye, who acquitted himself quite well in a one-score loss to the Bills a season ago in Buffalo. That Patriots team was in much worse shape than the one we’ll see in this game, and the Bills defense was likely a bit better (and certainly less injured) than the one Maye will face on Sunday. This is a game that should be more of a shootout than what most would expect from an AFC East battle, and I’ll take New England to put up some points and keep this within one possession.

Don’t miss our expert’s Patriots vs Bills predictions