NFL Week 6 Parlay: Expert 5-leg NFL Parlay Picks for Sunday, October 12 at HUGE +2408 odds!

Week 6 of the NFL season is in the books and what a week it was. There was plenty of drama across the slate, including a pretty significant upset win for the Patriots over the Bills in Buffalo. While I was unable to cash in on my Week 5 mega parlay, I did cash back in Week 1 at +2512 odds! Can we make it a second winner this week? It’s time to find out. With the Week 6 Sunday slate on the horizon, let’s get right into my NFL Week 6 mega parlay that pays out at over 24/1 odds at FanDuel Sportsbook.

Seahawks ML (-110)

Chargers -3.5 (-114)

Cardinals +8.5 (+100)

Cowboys -3 (-115)

Patriots vs Saints under 46.5 (-120)

NFL Week 6 parlay odds: +2408

Seattle Seahawks ML over Jacksonville Jaguars (-110)

This is an ideal spot to sell high on the Jaguars following their comeback victory against the Chiefs on Monday Night Football. Trevor Lawrence and company have benefitted massively from turnovers, including a pick-6 to turn the tide of last week’s game, so we can expect a bit of regression to the mean in that department for the Jaguars this week. Conversely, Seattle was probably a bit unlucky to lose to the Buccaneers at home a week ago, as the Seahawks committed a pair of costly turnovers, with both miscues resulting in points for Tampa Bay. Look for Sam Darnold and company to bounce back against a Jaguars team that is probably at the peak of its market value.

Grab our expert’s best bets for NFL Week 6

Los Angeles Chargers -3.5 over Miami Dolphins (-114)

After an excellent 3-0 start to the season, the Chargers have fallen on hard times in recent weeks, dropping each of their last 2 games in the favorite role. However, this game presents Los Angeles with a chance to bounce back, and it will certainly get a favorable matchup to do so. Justin Herbert has struggled in consecutive weeks, but Sunday’s contest should provide the Oregon product with a chance to get a bit of his confidence back against a Miami defense that is 31st in EPA per pass and 32nd in success rate allowed. Conversely, the Dolphins passing attack appears to have taken a massive hit without Tyreek Hill in the lineup, and it’s hard to see Miami having success against an excellent Chargers secondary. Let’s lay the points with Los Angeles.

Arizona Cardinals +8.5 over Indianapolis Colts (+100)

This is a game where we have a clear “buy low” spot on the Cardinals, while we can also “sell high” on a Colts team that is probably at the peak of its market value. After surrendering a double-digit fourth quarter lead to the Titans in a massively improbable loss a week ago, the Cardinals have picked up a trio losses by a combined 5 points over the last 3 weeks. It doesn’t get much more unlucky than that, and Arizona should be in for a bit of positive regression on Sunday, even with Kyler Murray expected to miss this game. We know that Jonathan Gannon’s team can keep this one close against Daniel Jones and Indianapolis, and the best part is we don’t need Arizona to win outright for us to cash this wager. Let’s look for another one-score game here.

Read our full Cardinals vs Colts predictions

Dallas Cowboys -3 over Carolina Panthers (-110)

The Cowboys are certainly one of the more entertaining units in the NFL, but while I tend to stay away from wagering on this version of the Dallas defense, I actually like the spot that this team find itself in on Sunday. The Panthers are coming off a game against a Miami Dolphins team in which they were pretty fortunate to win, and now they’ll have to take on a Cowboys offense that is one of the best in the game on a short week. While the Cowboys are certainly lacking on the defensive side of things, this is a Panthers offense that is getting a lot of credit for a couple of solid performances against bad defenses. If Dallas can load the box and focus on stopping the Rico Dowdle and the Panthers ground attack, this should put the Cowboys in a good position to win. We’ll lay the short number with the Cowboys.

Don’t miss our full Cowboys vs Panthers predictions

New England Patriots vs New Orleans Saints under 46.5 (-120)

To close out our mega parlay, we’ll back the under in what should be a lower scoring game than what the market is anticipating in New Orleans. Both of these offenses have been pretty competent this season, but the Patriots are in a prime letdown spot following an emotional victory over the division-leading Buffalo Bills on the road a week ago. New Orleans’ defense has been pretty stingy against the pass and the Patriots aren’t exactly an efficient team when it comes to running the ball. This is a game where New England could come out a bit flat and I could see the Saints struggling against a Patriots defense that has shown itself to be pretty opportunistic this season.

Don’t miss our expert’s Patriots vs Saints predictions