We have another loaded slate of college football action ahead of us this weekend, and the action kicks off on Friday with a matchup between the Northwestern Wildcats and USC Trojans at the Los Angeles Memorial Coliseum on FOX. This is a matchup between a couple of teams with different aspirations, as USC is still in the College Football Playoff hunt while Northwestern is looking to make a bowl game for just the 2nd time in the last 6 seasons. What side will come out on top in this one? It’s almost time to find out.
With so much intrigue in this Week 11 game of the 2025 college football season, a Northwestern vs USC Same Game Parlay is in order. Here are my favorite parlay picks for this matchup, while you can also find out our CFB picks for more than 30 matchups on Saturday’s super slate.
USC to win by 1-14 points (+150)
Makai Lemon (USC) anytime touchdown scorer (-110)
Northwestern vs USC Same Game Parlay odds: +425
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USC Trojans to win by 1-14 points over Northwestern Wildcats (+150)
Northwestern has shown an ability to play to its level of competition this season. After all, the Wildcats just covered the spread on the road as an underdog of over a touchdown against Nebraska a few weeks ago, and before that they also covered the spread against Oregon and won outright against a much healthier Penn State team on the road. Against a USC defense that has struggled against the run, we can expect the Wildcats to keep the ball on the ground and chew up clock in order to keep the Trojans offense off the field. Ultimately, I don’t see David Braun’s team quite keeping up with the Trojans’ elite offense on the west coast, but the Wildcats should be able to keep this one within the spread, which leads us to the first leg of our Same Game Parlay.
Read our full Northwestern vs USC prediction for tonight’s matchup on FOX
Makai Lemon (USC) anytime touchdown scorer (-110)
To close out our Northwestern vs USC Same Game Parlay, let’s focus on Makai Lemon to find the end zone for the 7th time this season. Lemon is one of the best wideouts in the nation and he’s been particularly effective when playing at home in this outstanding USC passing offense (top 3 in success rate and EPA per play). In fact, over the previous 4 home games the Trojans have played to this point, Lemon has tallied 4 touchdowns and nearly 500 receiving yards while racking up a whopping 28 receptions in the process. Look for the Trojans top wide reciever to see more success against the Northwestern secondary in a game where USC should score at least 27 points at home.
Find out our college football expert’s CFB best bet for Friday night, targeting Houston vs UCF
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