Premier League Predictions: EPL Picks & Best Bets for This Weekend - Brighton push Chelsea all the way

9/30/2023 - Brighton and Hove Albion's Adam Webster (left) attempts to stop Aston Villa's Ollie Watkins (right) from having a shot on goal during the Premier League match at Villa Park, Birmingham. Picture date: Saturday September 30, 2023. (Photo by Barrington Coombs/PA Images/Alamy Images/Sipa USA) *** US Rights Only ***
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Joe Casey

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The Premier League keeps hotting up and after 5 games, Liverpool remain top of the league with 5 wins. They will put their perfect record up against Crystal Palace – who have been very solid this season – on Saturday, while second-placed Arsenal face Newcastle on Sunday in the pick of the weekend’s action.  Here are all of our expert soccer picks for the weekend action in England, with the odds available at DraftKings Sportsbook at the time of publishing.

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EPL Best Bet: Brentford Win or Tie (Double Chance) vs Manchester United (-135)

Manchester United came out on top of a wild game last weekend, beating Chelsea 2-1 after the Blues goalkeeper Robert Sanchez was sent off after five minutes.

The Red Devils went two up before Casemiro was sent off and they ground out the win. However, there were not many signs of improvement for Ruben Amorim’s side, and it is hard to read too much into such an unusual game.

On the balance of their overall form, Manchester United are a hard team to support considering the struggles they have endured, losing to Grimsby in the cup and thoroughly outplayed by their rivals Manchester City.

They visit a Brentford team who have not been in the best form, but have avoided defeat the last three times that Manchester United have visited and look a decent bet to do so again.   

EPL Best Bet: Bournemouth ML over Leeds (+145)

Leeds may have picked up their second home win over the season against Wolves last weekend, but they will struggle to get their third against this Bournemouth team.

The Cherries rank second in OPTA’s expected points table, and their only loss has come against Liverpool on the opening day.

Andoni Iraola’s side were one of the most effective teams in the league on the road last season, and can get the better of a Leeds side who have only scored four times in five games – three of which came against Wolves last time out.

EPL Best Bet: Brighton Win or Tie (Double Chance) vs Chelsea (+100)

Brighton have faced Chelsea twice already in 2025 and won both games. They are a solid bet to avoid defeat when they visit the Blues in this Premier League clash.

Enzo Maresca’s side were beaten by Manchester United last weekend and followed that up with a far from convincing 2-1 win over Lincoln in the cup in midweek.

The hosts are in the middle of an injury crisis, with as many as 11 first-team players absent including Cole Palmer, Levi Colwill and Robert Sanchez.

Brighton have already beaten Manchester City and drawn with Tottenham this season, they can at least take a point from Stamford Bridge.

EPL Best Bet: Sandro Tonali to have two or more shots in Newcastle vs Arsenal (+265)

Sandro Tonali has been key in Newcastle’s midfield since his move from Milan, but he has taken a more attacking role in this team.

The Italian has had at least two shots in both of the Magpies’ home games and also took two shots last time out against Bournemouth.

Tonali should register at least two shots once more against Arsenal on Sunday.

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