Purdue vs Notre Dame Picks & Parlay: Same Game Parlay for College Football Week 4 at +430 odds

Jan 20, 2025; Atlanta, GA, USA; Notre Dame Fighting Irish running back Jadarian Price (24) runs with the ball against Ohio State Buckeyes safety Caleb Downs (2) during the first half the CFP National Championship college football game at Mercedes-Benz Stadium.
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Sam Avellone

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Long-time suffering Browns fan born and raised in the greater Cleveland, Ohio area who now resides in SEC country. University of South Carolina alum. Sports handicapper for close to 10 years with a primary focus on NCAAB while enjoying NFL, PGA, NCAAF, NBA, and Soccer. For Sam Avellone media enquiries, please email contact@pickswise.com.
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One of the biggest storylines of this young season is the 2025 National Championship runners-up sitting at 0-2, with both losses by a combined 4 points. Luckily for the Notre Dame faithful, the Fighting Irish welcome Purdue to South Bend on Saturday, which has historically been an opponent that teams can get-right against. I expect that to be the case here for the Irish, and have put together a Purdue vs Notre Dame Same Game Parlay at +430 odds for this contest in anticipation of that. Let’s analyze each leg of this SGP, and don’t forget to find our NCAAF picks for every major game this weekend.

Notre Dame -24.5 (-115)

Jadarian Price (ND) 90+ rushing yards (+260)

Purdue vs Notre Dame Same Game Parlay odds: +430

Odds available at Fanatics Sportsbook at the time of publishing.

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Notre Dame Fighting Irish -24.5 vs Purdue Boilermakers (-115)

This is a massive number to lay with a team that has struggled defensively like Notre Dame through 2 games. However, Purdue’s offense is nothing like that of Miami or Texas A&M. In fact, the Boilermakers are outside the top 75 in PPA per play, and they have failed to consistently finish quality drives with points. That’s going to be an issue against Notre Dame, who likely will have better luck finishing drives with touchdowns against this Purdue defense than USC did last week. For reference, USC travelled across the country and beat the Boilermakers at their house 33-17, though that score looks closer than the game felt. The Trojans outgained Purdue by more than 100 yards, but they had to settle for 5 field goals – one of which they missed. 

Despite being 0-2, Notre Dame has been exceptional in the red zone, finishing all 8 trips with points – 6 of them touchdowns. Meanwhile, Purdue has not been so fortunate. Despite playing one more game than the Irish, the Boilermakers have just one more red zone trip than them, and a third of their total red zone trips have ended without any points. Being at home and looking to make a statement against an inferior team playing its first true road game, look for Notre Dame to show out against Purdue on Saturday. Expect a much better defensive showing from the Irish in this matchup, too, as Purdue quarterback Ryan Browne is a turnover waiting to happen.

Read our full Purdue vs Notre Dame prediction

Jadarian Price (ND) 90+ rushing yards (+260)

Jeremiyah Love is certainly the focal point of Notre Dame’s rushing attack, but Jadarian Price is very much an integral part of it, as well. Coming off a career-high 27 touches, I wouldn’t be surprised to see Love have a reduced workload this week, especially if the Irish take an early lead. That would leave Price with a healthy share of carries, and he’s been explosive with the ball in his hands this season – averaging 6.3 yards per carry while sitting top 20 nationally in PFF’s breakaway percentage. 

Price was given 12 carries last week, and he had at last 10 carries on 5 different occasions last year. If he gets at least 10 carries in this matchup, I like his chances of breaking off multiple long runs and cashing some alternate rushing yards props against a Purdue defense ranked outside the top 85 in PPA per rush allowed and 79th in PFF’s tackling. For what it’s worth, Price surpassed 90 yards twice last year as Love’s backup, and he even had 86 in another game – so the ceiling is there. 

Find out our experts’ CFB best bets for our most confident picks of the weekend

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