Week 18 of the 2025 NFL season kicks off on Saturday, when the biggest game on the entire slate takes place between the Seattle Seahawks and San Francisco 49ers. Seattle comes in with a 13-3 record; San Francisco is 12-4. However, the 49ers would own the tiebreaker if they emerge victorious in front of their home fans. As such, the winner gets a coveted first-round bye in the playoffs; the loser has to settle for a wild-card spot.
I have been cashing Same Game Parlays left and right throughout the 2025 season, including 2 of my 4 efforts during Week 16 (+650 in Packers vs Bears and +600 in 49ers vs Colts). I also hit a +675 play for Texans vs Chargers last weekend. Let’s keep the momentum rolling with my SGP for this 8:00 pm ET kickoff on ESPN. Also be sure to check out our full Seahawks vs 49ers predictions.
Seahawks -1.5 (-112)
Jaxon Smith-Njigba Over 98.5 receiving yards (-112)
Christian McCaffrey to score a touchdown (-160)
Parlay odds: +550
Part of the value in a Same Game Parlay, of course, is that all of its components can be correlated if you so choose. That is some of the plan here, as Seattle receiver Jaxon Smith-Njigba racking up plenty of yards would obviously work well with a Seahawks win and cover. At the same time, plays that aren’t correlated drive up the overall payout of the parlay. That is the case with backing San Francisco running back Christian McCaffrey to score a touchdown. But even if he does, there is no reason why the visitors can’t get the job done. Let’s break down each of the 3 legs.
Seahawks -1.5 (-112)
San Fran may have home-field advantage, but Seattle has been a beast on the road all season long – boasting a 7-1 record away from home. Following a 2-point loss to the Rams in Week 11, the Seahawks have surged to a 6-game winning streak. This run includes revenge against L.A. in arguably the game of the year so far. Head coach Mike Macdonald’s crew also rolled to convincing wins and covers against the Vikings, Falcons and Panthers. Seattle is stacked with talent on defense (second in total EPA behind only Houston), while the offense – led by Sam Darnold and Jaxon Smith-Njigba — is doing more than enough to hold up its end of the bargain. The ‘Hawks are almost entirely healthy, too — not something you often see at this time of year. The Niners, on the other hand, are without edge rusher Nick Bosa and linebacker Fred Warner. With those 2 forces on the shelf, San Francisco’s defense has been struggling at times. The 49ers managed to beat the Bears this past Sunday night, but they surrendered 38 points in the process.
Jaxon Smith-Njigba Over 98.5 receiving yards (-112)
In what is the biggest game of the season, you have to figure that both teams will put the ball in the hands of their best players. For Seattle, of course, that is Smith-Njigba. The former Ohio State standout caught 9 of 13 targets for 124 yards in the first matchup with San Francisco and should be in line for another big night. He has surpassed the 100-yard mark 9 times this season and has recorded at least 92 receiving yards 4 other times. JSN now faces a San Fran defense that is #25 league wide against the pass at 235.6 yards per game allowed on 7.0 yards per attempt.
Christian McCaffrey to score a touchdown (-160)
I’m not overly concerned with throwing this into a parlay that also includes Seattle covering. After all, we can basically treat McCaffrey finding the endzone as a given. As long as the Seahawks contain everyone else, they should be in good shape even if McCaffrey delivers his normal output. The Stanford product has scored 17 touchdowns this season (10 rushing, 7 receiving). He has scored at least 1 TD in 6 consecutive contests – a stretch that includes a 2-touchdown performance and another with 3.
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