Caleb Wilfinger
Week 4 of the 2025 NFL regular season is upon us, and it is highlighted in part by a Thursday Night Football showdown between the Seattle Seahawks and Arizona Cardinals. It is a rare primetime game for the Seahawks and the first of the season for the Cardinals. Here are my Seahawks vs Cardinals TD scorer best bets for this NFC West matchup on TNF, and also be sure to check out our NFL picks and full Seahawks vs Cardinals predictions, with our experts boasting a 55-40-1 record so far this season for +27 units!
Seahawks vs Cardinals anytime touchdown scorer best bet: Jaxon Smith-Njigba (+175)
Odds available at FanDuel Sportsbook at time of publishing.
Seattle’s path to victory in this game can happen in multiple ways, but regardless of how the Seahawks go about this contest, they’ll need to have some success through the air. On that front, Jaxon Smith-Njigba has built a good rapport with Sam Darnold through the first 3 weeks, putting up back-to-back games with 100+ receiving yards on at least 10 targets. We can expect the top Seattle wideout to be very involved in the passing game yet again on TNF, especially in the red zone, as he just caught a touchdown against the Saints last week. It’s hard to ignore backing the top Seahawks wide receiver to find the end zone in this NFC West battle, especially well into plus-money odds.
Add some extra excitement to TNF with our expert’s Seahawks vs Cardinals Same Game Parlay at +650 odds
Seahawks vs Cardinals anytime touchdown scorer best bet: Trey McBride (+190)
Odds available at bet365 at time of publishing.
On the Arizona side of things, the passing game has been extremely inconsistent to this point, as Kyler Murray has only put up 542 passing yards through the first 3 games of the campaign. The 7th-year quarterback has all the tools to succeed, but he just hasn’t been on the same page with the Cardinals’ wide receiving corps all season.
With that in mind, it’s nice to have tight end Trey McBride as a security blanket for Murray and this Arizona passing attack. McBride has played like the best tight end in the game to this point in the season, hauling in 17 receptions for 183 yards and a touchdown. Look for the top Cardinals’ pass catcher to be targeted on multiple occasions in the red zone, especially given the struggles of these wideouts. This is a solid price on arguably the most talented player in this game.
Prop Holliday has started the 2025 NFL season on a 6-2 run with his prop picks, including winners at +550 and +1100! Find out his best Seahawks vs Cardinals player prop bets for TNF
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