Seattle Seahawks vs Arizona Cardinals Same Game Parlay: NFL Parlay Picks for Thursday Night Football, Week 4 

Week 4 of the 2025 NFL season will begin with a showdown in the NFC West between the Seattle Seahawks and Arizona Cardinals. It is a huge matchup in a division that currently features all 4 teams with a winning record. Both Seattle and Arizona head into Thursday at 2-1, just 1 game behind a San Francisco 49ers squad that is riddled with injuries.

Here is my Same Game Parlay for the festivities, which get underway at 8:15 pm ET on Amazon Prime. Also be sure to check out our full Seahawks vs Cardinals predictions.

Cardinals ML (+102)  

Under 43.5 (-115) 

Trey Benson to score a touchdown (+110)

Parlay odds: +650

Part of the value in a Same Game Parlay, of course, is that all of its components can be correlated if you so choose. That is some of the plan here, as Arizona running back Trey Benson finding the endzone would obviously work well with a Cardinals win. At the same time, plays that aren’t correlated drive up the overall payout of the parlay. That is the case with also backing the under – but even if Benson scores a TD, there is no reason why this contest can’t be relatively low scoring overall.

Cardinals ML (+102)

The Seahawks may be a bit overrated after blasting the New Orleans Saints 44-13 in Week 3. It’s hard to describe just how bad New Orleans is, so it’s hard to put any stock in that result. It also remains to be seen how good of a win a 31-17 result against the Pittsburgh Steelers is, because I’m certainly not convinced by an Aaron Rodgers-led Pittsburgh club. Seattle is off to an 0-1 start in the NFC West, and a tough road date with Arizona could lead to an 0-2 mark. This isn’t a home game against New Orleans, folks. Instead, the Seahawks are going on the road during what is obviously a very short week for both teams. Minimal rest and preparation generally favors the home side, especially when all other things are equal – as they appear to be in this matchup. I’ll gladly back the Cardinals as home ‘dogs. 

Under 43.5 (-115)

I think an under pick works much better with Cardinals ML, because they may not be able to keep with the Seahawks in a high-scoring shootout. It’s much more likely that the home side prevails in somewhat of a defensive slog. After all, Seattle currently ranks second in scoring defense (15.7 points per game allowed) and first in opponent points per play. Arizona’s offense is nothing special, and now it is without RB1 James Conner for the remainder of 2025. If the Cards are successful on Thursday night, their defense will probably be the main reason. It is a unit that ranks fifth league wide in scoring (17.0 points per game) and top 10 in both yards per pass and yards per rush given up. The ‘Hawks have put up plenty of points, but they have faced some bad teams and they haven’t been able to run the ball. The Cardinals are certainly good enough defensively to contain a relatively one-dimensional outfit. 

Trey Benson to score a touchdown (+110)

Conner’s broken ankle means Benson is now the top running back in Arizona. Although the sample size is small, Benson has impressed in the early stages of his career. The Florida State product played in 13 games in 2024 and turned 63 carries into 291 yards (4.6 average) and 1 touchdown. Through 3 weeks this season he has rushed 21 times for 125 yards (6.0 average). The Cardinals’ wide receivers have combined for just 2 TDs so far this year (1 each for Marvin Harrison Jr. and Michael Wilson), so it’s not like this team is dead set on slinging the ball around in the red zone. At plus money, Benson has good value to score in his first start of the 2025 campaign.