Soccer picks: English Premier League parlay for this weekend (+791 odds), including Liverpool vs Arsenal & Southampton vs Manchester City

New Liverpool boss Arne Slot will hope to get off to a fine start at Anfield with Mohamed Salah on target against Brentford.
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Steve Palmer

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The end of the 2024-25 English Premier League season is almost upon us, with Liverpool confirmed as champions and the relegation places settled, but there are still some intriguing tussles this weekend as the battle for the European places intensifies. We’ve picked out a 4-game English Premier League soccer parlay for this weekend’s action, which pays at +791 odds with FanDuel Sportsbook. You can also find out our soccer picks for this weekend’s big EPL and MLS matchups.

Manchester City ML (-600)

Brentford ML (-160)

Bournemouth ML (+135)

Liverpool ML (+100)

EPL parlay odds: +791

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Manchester City ML over Southampton (-600), 10:00 am ET, Saturday

Morale has improved markedly at the Etihad Stadium in the last few weeks, with Man City in the FA Cup final and suddenly having high hopes of catching Arsenal for 2nd place in the Premier League. Pep Guardiola’s team should enjoy itself on the south coast of England on Saturday. Southampton have been relegated and are still without a manager, limping to the end of the season in sorry fashion. It is difficult to see the miserable Saints offering up much resistance to City’s high-class forward line. The Citizens should be the foundation of any Premier League parlays this weekend.

Find out all of our EPL soccer predictions for this weekend

Brentford ML over Ipswich (-160), 10:00 am ET, Saturday

Ipswich Town will be joining Southampton in the Championship next season – the Tractor Boys’ relegation was confirmed when they lost 3-0 to Newcastle at the end of last month – and confidence is extremely low at Portman Road. Expect buzzing Brentford to take full advantage of Ipswich’s malaise. The Bees are unbeaten in their last 5 matches and have won their last 3. They have faced top-class opposition in that period, with Chelsea, Arsenal, Brighton, Nottingham Forest and Manchester United providing the challenge.

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Bournemouth ML over Aston Villa (+135), 12:30 pm ET, Saturday

Bournemouth fans are dreaming of ending a magnificent season by securing European football next season and victory over Aston Villa can massively aid that cause. The Cherries have gone 5 matches unbeaten, defeating a full-strength Arsenal team last Saturday to stun the Gunners at the Emirates Stadium. Brazilian striker Evanilson and the rest of the Bournemouth team will be relishing the chance to build on that result by claiming 3 points against Villa. The visitors have lost their last 3 games and appear jaded at the end of a long season, which included 12 Champions League matches.

Read our full Bournemouth vs Aston Villa prediction

Liverpool ML over Arsenal (+100), 11:30 pm ET, Sunday

Liverpool vs Arsenal looked like it would be a hugely important game a few weeks ago, but Arsenal’s title challenge has ended in a whimper, and their Champions League hopes were dashed in Paris on Wednesday when they lost to PSG. Arsenal manager Mikel Arteta made the curious decision to field a full-strength team against Bournemouth last Sunday, so his key players have had 2 legs of a Champions League semifinal against Paris St-Germain, as well as a home loss to Bournemouth, to endure. Misery has suddenly overwhelmed the Arsenal locker room and another defeat seems likely at Anfield on Sunday.

Read our full Liverpool vs Arsenal prediction

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