Andrew Wilsher
Week 5 of the 2025 NFL season kicks off with an NFC West matchup between the San Francisco 49ers and LA Rams on Thursday Night Football. Both of these teams are 3-1 and will look to take control of the division, but the big story is that Brock Purdy has been ruled out for the Niners, meaning Mac Jones will be under center. 49ers vs Rams kicks off on TNF at 8:15 pm ET live on Amazon Prime Video, and here at Pickswise, we have everything you need to bet better! You can find out our NFL picks on the side and total, along with our experts’ best NFL player prop bets and Same Game Parlay picks. Let’s get into our TNF picks and 49ers vs Rams predictions.
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NFL 49ers vs Rams picks & TNF predictions
- 49ers vs Rams predictions — our experts have started the season with a 73-54-1 record on sides and totals for +37.1 units! Get Chris Farley’s picks for TNF
Best 49ers vs Rams player prop bets
- 49ers vs Rams player prop picks — Prop Holliday looks to add to his 7-4 start to the NFL season with his player prop bets for TNF, targeting Kyren Williams
- 49ers vs Rams touchdown scorer best bets — JutPicks’ top picks to find the end zone, including a longshot at +325 odds!
San Francisco 49ers vs LA Rams Same Game Parlay
- 49ers vs Rams Same Game Parlay — shoot for the bigtime with our expert’s SGP picks at +465 odds
NFL Week 5 predictions
Get set for more hot Week 5 action by checking out our experts’ picks and NFL predictions on the side and total for EVERY GAME this week, as we look to add to our 73-54-1 record this season!
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- Patriots vs Bills predictions for Sunday Night Football
- Chiefs vs Jags predictions for Monday Night Football
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