Week 3 College Football Parlay: CFB Parlay Picks for Saturday, September 13 at +843 odds

Ohio State Buckeyes wide receiver Carnell Tate (17) celebrates a touchdown catch with quarterback Julian Sayin (10) during the second half of the NCAA football game against the Texas Longhorns at Ohio Stadium on Aug. 30, 2025. Ohio State won 14-7.
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Sam Avellone

CFB

Long-time suffering Browns fan born and raised in the greater Cleveland, Ohio area who now resides in SEC country. University of South Carolina alum. Sports handicapper for close to 10 years with a primary focus on NCAAB while enjoying NFL, PGA, NCAAF, NBA, and Soccer. For Sam Avellone media enquiries, please email contact@pickswise.com.
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Week 3 of the 2025 college football regular season is loaded. As many as 3 ranked matchups headline Saturday’s action, while as many as 5 other ranked teams hope to avoid an upset on the road against an unranked foe. Not to mention that we will have nonstop college football action from noon ET until well after midnight out on the island, which is absolutely a perfect Saturday if I do say so myself. 

We didn’t cash in on last week’s parlay, but I’m feeling good about our chances of recreating our Week 1 magic with that +438 winner. Even with a 1-1 record, we are still well in the positive on these Saturday CFB parlays. With that being said, let’s get right into this week’s parlay consisting of some of my favorite picks for the third full Saturday of the season, and don’t forget to check out the rest of our NCAAF picks and best bets for the entire Week 3 card. 

Ohio vs Ohio State Over 51.5 (+110)

Georgia Tech ML (+130)

Arkansas team total Over 27.5 (-105)

NCAAF Week 3 Saturday parlay odds: +843

Odds courtesy of bet365 at the time of publishing

Ohio Bobcats vs Ohio State Buckeyes alternate total over 51.5 (+110)

If you followed my Ohio vs Ohio State prediction earlier this week, you already locked in over 51.5 in this contest. Unfortunately, we got a bad number. While the total ticked up to 52.5 at some shops, it has since dropped to 49.5 at most places in the market. I can see why the market moved, though I may not agree with the move itself.

It is expected that the Buckeye defense will shut down the Bobcats offense. On top of that, neither team has played with much pace in their FBS matchups, as both Ohio and Ohio State are outside the top 100 in seconds per play. However, nothing has changed on my end regarding how I perceive this game. Ohio State can single-handedly hit this over itself, which is something this program repeatedly does against MAC competition. For reference, the Buckeyes have surpassed 50 points against each of the 5 MAC representatives it has placed since 2019.

The Buckeyes should have a clear talent advantage in this matchup, and while they may operate at a slower-than-average pace, their explosiveness is what sets them apart from an opponent like this. I don’t see any way the Ohio secondary contains Jeremiah Smith or Carnell Tate. I’m staying strong on my early-week stance for the over in this contest, so much so that I’m going to use an alternate line to get plus-odds on my original bet as a way to juice up the overall odds of this parlay.

Georgia Tech ML over Clemson Tigers (+130) 

Speaking of juicing up the odds of the parlay, let’s include a money line underdog. 

Georgia Tech was my preseason pick to win the ACC at 14/1. When I made that bet, I had this game circled as a spot in which the Yellow Jackets would make their presence felt in the conference. Little did I know that Clemson would look so bad not only against LSU, but also Troy, leading into this game.

Clemson’s offense has not played with the chemistry and explosiveness that we thought it would coming into the season. Some of that has to do with injuries, as starting OL Tristan Leigh and WR Antonio Williams have missed time and are currently questionable for this contest, but the Tigers simply have not looked the part thus far. That won’t cut it this weekend against a Georgia Tech offense that can put up points in bunches. 

Yes, the Tigers have controlled this series of late, but they also have had issues away from home over the last 2 years. In fact, they have covered just 4 of 10 regular-season spreads away from Death Valley since the start of the 2023 season. Look for Jamal Haynes and a fresh Haynes King, who practiced in full on Tuesday and was not in the initial injury report on Thursday, to leave it all on the line and lead the Jackets to a win over Clemson.

Read our full Clemson vs Georgia Tech prediction, including picks on the side and total

Arkansas Razorbacks team total Over 27.5 vs Ole Miss Rebels (-105)

Arkansas and Ole Miss have played each other every year since 1981. It’s been quite a fun rivalry in recent years, not to mention very high-scoring. Moreover, Arkansas has been a cash cow against the number in this series, covering in 8 of the 10 meetings since 2015. Six of the 10 have been decided by a touchdown or less. 

With Bobby Petrino at the helm and Taylen Green under center, this Arkansas offense is lethal. The Hogs have surpassed 50 points in both of their games thus far, and while Ole Miss is an obvious step up in class in their first road game, the Rebels haven’t exactly been inspiring defensively — surrendering 5.5 yards per rush against Georgia State and over 350 total yards to a Kentucky team that really struggles to throw the ball.

This game should have plenty of tempo, which only works to our advantage. With both teams currently in the top 20 in seconds per play, expect plenty of possessions leading to multiple scoring opportunities for a Razorback offense that has been highly efficient right out of the gate. Because Arkansas is the underdog in this matchup, we have a great opportunity to snag an over on a team total that sits below a key number, so let’s do just that to round out this Saturday NCAAF parlay.  

Now check out our Arkansas vs Ole Miss prediction

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