Week 8 College Football Parlay: CFB Parlay Picks for Friday, October 17

Louisville Cardinals quarterback Miller Moss (7) scores on this touchdown run in the first quarter during the Cards' 51-17 win over Eastern Kentucky University at the Cardinals' season opener Saturday, August 30, 2025 at L&N Federal Credit Union Stadium in Louisville, Kentucky.
Photo of Caleb Wilfinger

Caleb Wilfinger

CFB

Deputy Editor for Pickswise with years of experience handicapping and giving out winning picks. Lover of all US sports and Southampton FC. For Caleb Wilfinger media enquiries, please email contact@pickswise.com.
Read more about Caleb Wilfinger
Google News

Week 8 of the college football season is nearly here, and Friday presents another opportunity for bettors to jumpstart their bankrolls ahead of Saturday’s massive college football slate. There aren’t many games on the schedule, but we have enough games on the slate to assemble a parlay consisting of a few of our favorite bets of the evening. Here are our NCAAF parlay picks for Friday, October 17, and don’t forget to check out our college football predictions for all of Week 8’s mega matchups.

Louisville +13.5 (-105)

Minnesota +7.5 (-125)

California -8.5 (-105)

CFB Friday parlay odds: +583

Head to bet365 to get the best odds on our college football Friday parlay picks, where new users can click here to join now and receive $200 in bonus bets INSTANTLY when they make their first $5 wager — win or lose!

Louisville Cardinals +13.5 over Miami Hurricanes (-105)

From a numbers perspective, it’s hard to get there with Louisville as a 2-touchdown underdog in this spot. Head coach Jeff Brohm has historically been very profitable in the underdog role, and he’ll be opposing a head coach in Mario Cristobal that has certainly had his struggles as a double-digit favorite in conference play.

While Miami appears to be one of the best teams in the nation this season, the Hurricanes defense has been a middling unit when it comes to allowing points once the opponent crosses their 40-yard line. Louisville’s defense is quite strong (11th in success rate allowed) and the Cardinals also much healthier on offense following a bye week. I trust the veteran presence of Miller Moss to have the Cardinals ready to execute in this one on the road.

Grab our expert’s full Louisville vs Miami prediction 

Minnesota Gophers +7.5 over Nebraska Cornhuskers (-125)

For the 2nd leg of our Friday evening CFB parlay, let’s take the home underdog to keep this Big Ten clash within a possession. For starters, this is a good spot for Minnesota, as the Gophers will be playing their third home game over the last four weeks, and they’ll host a Nebraska team that is playing its second straight road game in conference play.

Furthermore, the Cornhuskers could’ve easily lost a week ago to Maryland, as Matt Rhule’s team needed 10 points in the 4th quarter to stave off the upset in College Park. That followed a game in which Nebraska had significant special teams and turnover luck in a flukey 11-point win over Michigan State, which has already not aged all that well following last week’s results. This one should be a close, low-scoring affair in Minneapolis.

Read our full Nebraska vs Minnesota prediction

California Golden Bears -8.5 over North Carolina Tar Heels (-105)

The final leg of our CFB parlay takes us out west, where we’ll lay the points with California at home against a North Carolina team that has been an absolute mess all season long. The Tar Heels have been flat out non-competitive in each of their 3 losses to this point, with the most embarrassing result coming to Clemson in their ACC home opener on October 4.

Now, Bill Belichick’s group — a team that might’ve already quit on the season — has to head to the west coast for a date against a California side that is coming off a bye week following a deflating loss at the hands of Duke. Luckily for Justin Wilcox’s group, this North Carolina offense (115th in success rate, 119th in points per drive) is nothing like what the Bears saw against Duke, or even San Diego State a few weeks ago. We can only look at Cal on Friday.

Read our full North Carolina vs California prediction

Google News
Stay up to date with the latest picks, odds, and news!
Click here to add us to your Google preferred sources and never miss a story
Pickswise
*
By signing up you agree to our terms and privacy policy