Matt Ryan playing quarterback for the Kansas City Chiefs

NFL upset picks for every week of the season. Get our best underdog NFL picks for those barking dogs who some bettors think are silly underdog picks but we don’t and see them as live chances to cash. If you want our plays for all other NFL games then head over to our NFL picks homepage. We have free picks for every game on the slate and a weekly parlay.

Underdog winners keep coming as Week 10 has a lot more NFL Best Underdog picks heading your way.

Pickswise NFL Best Underdog Pick Record: 19-9-1

Carolina Panthers vs. Green Bay Packers

Very interesting game here as the Green Bay Packers host the Carolina Panthers. The Panthers bounced back with a big win over the Titans in Week 9, while the Packers suffered an unexpected loss at the hands of the Chargers. I’ve been high on this Carolina team all year long, and I think they’re going to march into Green Bay here and put up a heck of a fight. The Packers clearly weren’t playing as well as their record indicated, and it wasn’t that surprising that they got exposed by the Chargers this past week. They’ve been getting pretty fortunate, and I think the loss to Los Angeles could be a sign of things to come. Kyle Allen had a nice bounce-back game against Tennessee, I think he should play better moving forward now that he no longer has Cam Newton breathing down his neck after Newton was placed on injured reserve. The Chargers just saw their lifeless rushing attack get rejuvenated against Green Bay’s run defense, so I think Christian McCaffrey’s in for a big day here. Take the points with the Panthers all day long. Pick: Panthers +5.0 is another play of the day!

Arizona Cardinals vs. Tampa Bay Buccaneers

From weeks five through seven, the Arizona Cardinals were starting to showcase the power this new offense has. Winning three straight games and scoring at least 26 points, the Cardinals were ready for their first big test against the New Orleans Saints in week eight. Unfortunately, the test was too big for them as they fell by the final score of 31-9. However first-year head coach Kliff Kingsbury proved he could bounce back against a top team in the league as the Cardinals nearly took down the undefeated 49ers on Thursday night football. With covering the spread in four of the past five games, the Cardinals are ready to unleash their new running game. This new running game will feature the return of David Johnson from injury as well as new Cardinal Kenyan Drake who had 162 yards from scrimmage last week in his debut with the team. The Cardinals are 4-1 ATS in their last 5 road games as well as 4-1 ATS in their last 5 games overall too. This Cardinals team is hungry to stay in the NFC West fight and take on a Buccaneers team that simply cannot finish. The Buccaneers have kept it close in pretty much all of their games this season but as favorites, there is no way to trust a quarterback who has over 20 turnovers this season. Give me the Cardinals +4.5 as well as sprinkling some money line on them is also a great bet.

Atlanta Falcons vs. New Orleans Saints

Classic rivalry game here as the New Orleans Saints host the Atlanta Falcons. The Falcons might be in a state of disarray, but they always get up for these games against their division rivals. Coming off the bye week, I think we could see a homerun effort from them here. Matt Ryan is returning after missing a game with an ankle injury, and the whole team has a pretty big chip on their shoulder. The Saints have rightfully been on the receiving end of a ton of Praise, but I think the hype train has gotten a bit out of control. The Falcons have been having a very rough season but they are by no means a complete doormat, and if the Saints are getting complacent with this one and they are going to be in for a rude awakening. Falcons still has plenty of weapons on offense, so they won’t be out-gunned here. The spread is simply too large at +13.0 and you have to take the points with the visitors.