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IND
Indianapolis Colts
Oct 49:30 AMTottenham Hotspur Stadium, London
WAS
Washington Commanders
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IND vs WAS Prediction, Odds and NFL Picks for Sunday, 10/04/26

IND
WAS
Indianapolis ColtsWashington Commanders
NFLSun, Oct 49:30 AM
Best BetValue PickPoint Spread Pick

When Washington and Indianapolis invade England, the question becomes: can the Commanders take command, or will the Colts buck and kick them where it hurts? Last weekend, Indianapolis finally earned its first win of the season -- edging out a victory over Houston by two points on a field goal after the two-minute warning. Washington also picked up its first win, knocking off the reigning Super Bowl champion Seahawks. The catch? Neither team may be as bad as its record suggests, as both have battled key injuries and suffered a string of close losses. However, if talent alone tips the scales, the Colts may hold a slight edge.

The Commanders enter Sunday's matchup without starting quarterback Jayden Daniels, who dislocated his left elbow in Dallas in a game Washington likely wins if he doesn't go down. Marcus Mariota proved capable in the victory over Seattle, but he will face a Colts secondary that has found its footing. Indianapolis held Houston to 17 points and pushed Kansas City to overtime, and that recent defensive surge is a big reason I believe the Commanders come up short across the pond.

Both teams have traveled a similar road to this point in the season. However, Indianapolis' recent spark on defense -- combined with its collection of offensive weapons -- should prove too much for Washington to overcome. Star receiver Alec Pierce won't suit up on Sunday, but quarterback Daniel Jones still has plenty of playmakers at his disposal. I expect the Colts to eclipse their team total and finish at least four points clear of the Commanders, comfortably covering the spread.

Colts vs Commanders prediction: Colts -3.5 (-110) available at time of publishing. Playable to -4.5.

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