Colorado Avalanche vs Buffalo Sabres Predictions, Odds and Picks for Today, 11/13/25

The Buffalo Sabres travel to Colorado to take on the Avalanche for the final time this season. These teams met back in mid-October in what was a relatively tight hockey game. There’s no question that this game will be a mismatch. It’s hard to envision a scenario where things don’t get out of hand for Buffalo. They are 0-4-2 on the road, playing the second game in as many nights, allow over 30 shots against per game, and have to deal with the highest-scoring offence in the NHL.

Colorado is scoring 4 goals per game and has gotten some fantastic goaltending from Scott Wedgewood. MacKenzie Blackwood is likely to start this game, but that isn’t a massive downgrade. The only thing that can slow them down is their mentality. If they come into this game thinking it will be easy, then they could be in trouble. The Avalanche are elite in almost every offensive category, and if they come out with pace and get pucks on goal, they should have no problem covering the Puck Line by a wide margin.

Sabres vs Avalanche prediction: Colorado Avalanche -1.5 (-135) at the time of publishing. Playable at that number or better.

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