Calgary Flames vs Buffalo Sabres Prediction, Odds and Picks for Today, 11/19/25

The Calgary Flames and Buffalo Sabres are set for a Wednesday night tilt at KeyBank Center in Buffalo. After dropping 5 games in a row, the Sabres have bounced back with back-to-back wins over the Red Wings and Oilers. They trailed Detroit 4-1 before mounting an impressive comeback to win 5-4 in overtime, and that win seems to have sparked the Sabres. They went on to rout Edmonton 5-1 on Monday and are now set to host a struggling Calgary team on home ice. Looking to keep the momentum going, the Sabres are in a solid position to win their third consecutive game.

Having Rasmus Dahlin back in the mix is a huge plus for Buffalo. The Sabres struggled in his recent absence but are a much better team with him on the ice. Furthermore, this is a tough scheduling spot for the Flames — who will be playing the second half of a road back-to-back. They lost in Chicago 5-2 last night and are just 2-9-1 on the road so far this season. The Flames rank dead last in the NHL in goals per game with 2.10 and their powerplay percentage of 12.7% is also the worst in the league. Take confidence in backing the Sabres for this Wednesday night matchup.

Flames vs Sabres prediction: Buffalo ML (-150) available at time of publishing. Playable to -165.

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