Columbus Blue Jackets vs Buffalo Sabres Prediction, Odds and Picks for Today, 10/28/25

The Buffalo Sabres started slow this season, but have turned things around a bit. Over their first 3 games to open the new campaign, Buffalo went 0-3 and managed to score just 2 total goals. Since then the Sabres are 4-2 and are scoring 4.2 goals per game. The Blue Jackets haven’t exactly been great defensively and in net, as they’ve allowed 3.13 goals per game this season and have allowed 9 goals over their last 2 games. Look for Buffalo to keep rolling offensively in this one.

The Blue Jackets have been a volatile team so far in 2025. They enter this matchup with a 4-4-0 record, winning each of their last 3 road games. But how long can that streak last? Going on the road to face a Sabres team that is scoring goals with ease lately presents a tough task. Furthermore, Buffalo has won 4 straight home games with all 4 wins coming by multiple goals. The home team has won 4 of the last 5 meetings between these teams, and with the Sabres rolling the way they are, look for Buffalo to defend home ice with a win on Tuesday night.

Blue Jackets vs Sabres prediction: Sabres ML (-120) available at time of publishing. Playable at that number.