Edmonton Oilers vs Ottawa Senators Prediction, Odds and Picks for Today, 10/21/25

This number has value given that the over is 5-1 through the Senators’ first 6 games of the season. While Ottawa has scored 4+ goals in 4 out of their 6 games played, it has been their lack of goal prevention that has been the primary driver behind high game totals. It is also the reason the Senators are 2-4-0. If Ottawa continues to produce offensively but struggle on the other side of the puck, it should be a great recipe for another high-scoring affair.

Edmonton has allowed 13 goals over their last 3 games for an average of 4.33 goals allowed during that span. That alone bodes well for game total overs. Add in the Oilers’ goal-scoring prowess, and the over has even more appeal. While Edmonton has been somewhat snake bitten over the last few games, they have a couple of the best players in the world that have a favorable matchup against a Senators team struggling to prevent goals. This one has the makings of another over.

Senators vs Oilers prediction: Over 6 (-110) available at the time of publishing. Playable to 6.5.

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