Ottawa Senators vs Florida Panthers Prediction, Odds and Picks for Today, 10/11/25

The Florida Panthers are off to a 2-0 start thanks to a pair of tightly-contested 1-goal wins over the Blackhawks and Flyers. The back-to-back defending Stanley Cup champions look a little different in 2025-26, as stars Matthew Tkachuk and Aleksander Barkov are both sidelined with major injuries. Barkov’s absence is arguably more significant, as the Florida offense tended to cycle around him. The puck was on his stick a lot, and while Florida still has plenty of scoring depth, not having the services of such a polished playmaker such as Barkov is a big loss.

The Senators are looking to complete an early-season Florida sweep, as they are coming off an impressive 5-4 win over the Lightning on Thursday. Ottawa fell down 3-1 in the first period but came storming back to score 4 consecutive goals en route to a comeback victory. It was a complete effort for the Senators, as they out-shot Tampa Bay 34-25 and controlled the face-off dot 30 to 25. The Senators play a physical brand of hockey that is capable of giving the new-look Panthers some issues. As the underdogs, consider a small wager backing the Senators on the road in this one.

Senators vs Panthers prediction: Ottawa ML (+125) available at time of publishing. Playable at that number.

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