St. Louis Blues vs Buffalo Sabres Prediction, Odds and Picks for Today, 11/06/25

The St. Louis Blues are looking to bounce back after suffering a 6-1 loss to the Washington Capitals on Wednesday night when they battle the Buffalo Sabres on Thursday. The Blues have been arguably the most disappointing team in the NHL so far this season. Nothing has gone right for Jim Montgomery’s team early on, as they enter this contest with a measly 4-8-2 record. They are allowing the most goals per game in the league, and both Jordan Binnington and Joel Hofer have struggled mightily between the pipes. Binnington got the start on Wednesday, but he was pulled in the 2nd period after allowing 4 goals on 15 shots. No matter who gets the starting nod in this one, the Sabres should be able to find success offensively.

The Sabres have yet to win a game on the road this season, but the good news is that they are playing this game on home ice. They’ve won 5 of their 9 home games, with 2 of those 4 losses coming past regulation time. The Sabres have just 1 win over its last 5 games, but all 4 losses during that stretch came in overtime. This is the final game of a 3-game home stand for the Sabres, so they’ll be eager to wrap up the home stand with a win. Playing on the back half of a road back-to-back makes this an even tougher uphill battle for the Blues. Back Buffalo in this one.

Blues vs Sabres prediction: Sabres ML (-130) available at time of publishing. Playable at that number.