St. Louis Blues vs Calgary Flames Prediction, Odds and Picks for Today, 10/11/25

The St. Louis Blues and Calgary Flames meet for an afternoon Western Conference battle as part of a massive 16-game slate in the NHL. These teams have combined for a 1-2-0 record to begin the NHL season, but have given up a combined 13 goals (4.33 goals against per game). There is lots of work to be done within each team, and this could be a great momentum builder. To get you set, here are our Blues vs. Flames predictions.

The Blues are not expected to do anything exceptional this season, but they were straight up embarrassed to begin this season, in a 5-0 loss on home ice to the Minnesota Wild. They may not have any of the top players in the league, but they are deep and esteemed enough where that is an unacceptable result. They now have a great opportunity against a young and rebuilding Flames team on the road. In a bounce-back effort, I expect the Blues to win.

Blues vs Flames prediction: St. Louis ML (-130) available at time of publishing. Playable to -140.

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